A new method for the synthesis of 3-hydroxymethylbenzofuran  

作　　者：Huan Luo Yan-Fei Liu Chun-Lei Zhang Yan Wang Gang Ni De-Quan Yu 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College

出　　处：《Chinese Chemical Letters》2013年第12期1115-1117,共3页中国化学快报（英文版）

基　　金：supported by the National Mega-Project for Innovative Drugs (No. 2012zx09301002-002);State Key Laboratory of Bioactive Substance and Function of Natural Medicines

摘　　要：A new one-step synthesis of 3-hydroxymethylbenzofuran, based on intramolecular cyclization of 2- （methoxymethyl）-2-（2＇-methoxymethyl-4＇-methylphenyl）-butanone I under diluted hydrochloric acid in THF, was developed. The mechanism for this process was investigated via chemical equilibrium shift of tautomer in acidic conditions. The applicability of this new method was studied further in this paper.A new one-step synthesis of 3-hydroxymethylbenzofuran, based on intramolecular cyclization of 2- （methoxymethyl）-2-（2＇-methoxymethyl-4＇-methylphenyl）-butanone I under diluted hydrochloric acid in THF, was developed. The mechanism for this process was investigated via chemical equilibrium shift of tautomer in acidic conditions. The applicability of this new method was studied further in this paper.

关 键 词：3-Hydroxymethylbenzo furan derivatives Mechanism Tautomer 

分 类 号：O621.3[理学—有机化学]