Synthesis and biological evaluation of novel 1,2,4-triazole containing 1,2,3-thiadiazole derivatives  

作　　者：Yue-Dong Li Wu-Tao Mao Zhi-Jin Fan Juan-Juan Li Zhen Fang Xiao-Tian Ji Xue-Wen Hua Guang-Ning Zong Feng-Yun Li Chao-Lun Liu Jian-Hua Yu 

机构地区：[1]State Key Laboratory of Elemento-Organic Chemistry,Nankai University [2]Division of Hematology,College of Medicine and School of Public Health,The Ohio State University

出　　处：《Chinese Chemical Letters》2013年第12期1134-1136,共3页中国化学快报（英文版）

基　　金：funded in part by the NSF of Tianjin (No. 10JCZDJC17500);the National Key Project for Basic Research (No. 2010CB126105);National Key Technology Research and Development Program (No. 2011BAE06B02);the Foundation of Achievements Transformation and Application of Tianjin Agricul-tural Science and Technology (No. 201002250);Tianjin Key Technology Research and Development Program (No. 11ZCGYNC00100)

摘　　要：A series of novel 1,2,4-triazoles containing 1,2,3-thiadiazole derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, 1H NMR, and elemental analysis and ESI-MS or HRMS. Preliminary bioassays indicated that these compounds exhibited very good insecticidal activity against Aphis laburni at 100 μg/mL, with mortality no less than 95%. Compounds 6a, 6c, 6f, 61 showed higher curative activity against TMV and compound 6h showed a higher induction effects against TMV in vivo at 100 μg/mL. Collectively, our data demonstrate a new strategy for control of insects and viruses.A series of novel 1,2,4-triazoles containing 1,2,3-thiadiazole derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, 1H NMR, and elemental analysis and ESI-MS or HRMS. Preliminary bioassays indicated that these compounds exhibited very good insecticidal activity against Aphis laburni at 100 μg/mL, with mortality no less than 95%. Compounds 6a, 6c, 6f, 61 showed higher curative activity against TMV and compound 6h showed a higher induction effects against TMV in vivo at 100 μg/mL. Collectively, our data demonstrate a new strategy for control of insects and viruses.

关 键 词：1 2 3-Thiadiazole 1 2 4-Triazole Insecticidal activity Anti-TMV activity 

分 类 号：O621.3[理学—有机化学]