全麻手术对患者血小板CD62p和CD63表达的影响  

The influence of surgery under general anesthesia to CD62p and CD63 of platelet

作　　者：王升[1] 庞雁[1] 康红灿[1] 李新刚[1] 

机构地区：[1]河南安阳地区医院血液实验室,安阳市455000

出　　处：《实用检验医师杂志》2013年第3期179-181,194,共4页Chinese Journal of Clinical Pathologist

摘　　要：目的观察全麻手术后血小板CD62p和CD63的变化,探讨全麻手术对血小板活化的影响。方法利用流式细胞术检测112例全麻手术患者麻醉诱导前、手术结束后、术后3 d血小板CD62p和CD63表达水平,并进行统计学分析。结果手术结束后及术后3 d的CD62p表达水平分别与麻醉诱导前比较,差异均无统计学意义(P均>0.05);手术结束后的CD63表达水平与麻醉诱导前比较,差异有统计学意义(P<0.05),但术后3 d与麻醉诱导前比较,差异无统计学意义(P均>0.05)。结论全麻手术后血小板的活化有明显的增强,增加患者术后发生血栓的风险。Objective To monitor the levels of CD62p and CD63 of platelet in patients accepted surgery under general anesthesia and to explore the influence of surgery under general anesthesia to activated state of platelet. Methods Flow cytometry was used to measure the levels of CD62p and CD63 of platelet （before the general anesthesia, immediately after the surgery, three days after the surgery） in 112 patients received surgery under general anesthesia, and the results were analyzed statistically. Results The level of CD62p in immediately after the surgery and three days after the surgery were all higher than in before the general anesthesia, but the differences were all had no statistical significance （Pall〉 0.05 ）. The level of CD63 in immediately after the surgery was higher than in before the general anesthesia, and the difference had statistical significance （P〈 0.05）, but there was no statistical significance in the difference of CD63 level between three days after the surgery and before the general anesthesia （P〉 0.05）. Conclusion There is visible reinforcement activated of platelet after surgery under general anesthesia, which increase the risk of thrombus.

关 键 词：全麻手术 流式细胞术 CD62P CD63 

分 类 号：R614[医药卫生—麻醉学]