复方替硝唑栓剂的制备及质量控制  

Preparation and Quality Control of Compound Tinidazole Suppository

作　　者：王震[1] 朱兴年[1] 冒镇[1] 景荣芳[1] 季惠娣[1] 

机构地区：[1]江苏省海安县人民医院,海安县226600

出　　处：《中国药房》2000年第4期158-159,共2页China Pharmacy

摘　　要：:目的 :制备复方替硝唑栓剂 ,制定质量控制标准。方法 :以S-40为栓剂基质 ,替硝唑、氧氟沙星、酮康唑为主药 ,制备复方替硝唑栓剂 ,并用紫外分光光度法测定含量。结果 :替硝唑、氧氟沙星、酮康唑平均回收率分别为98 10 %、104 05 %、102 40 %。RSD分别为1 62 %、1 33 %、0 68 %。结论 :复方替硝唑栓剂制备工艺简单、含量测定操作简便。OBJECTIVE:To prepare the compound tinidazole suppository and establish the quality control standard.METH_ODS:Taking S-40 as the base material and tinidazole,ofloxacin and nigoral as main ingredients,the compound tinidazole suppository was prepared.The UV-spectrophotometry was used for quantitative analysis.RESULTS:The average recovery rates of tinidazole,ofloxacin and nigoral were 98.10%、104.05% and 102.40%and their RSDs were 1.62%、1.33%and 0.68% respectively.CONCLUSION:The preparation of compound tinidazole suppository is easy in technological process.The method of content determination is simple and accurate.

关 键 词：复方替硝唑栓 替硝唑 氧氟沙星 酮康唑 制备 质量控制 

分 类 号：R978.1[医药卫生—药品] TQ465[医药卫生—药学]