缓慢牵伸肢体延长周围神经损害自然修复过程的组织学研究  

Histological Investigation on the Natural Repairing Process of Peripheral Nerves after Tibial Lengthening in Rabbits

作　　者：范少地[1] 许建中[1] 李起鸿[1] 钟桂午[2] 

机构地区：[1]第三军医大学西南医院骨科,重庆400038 [2]解放军第451医院骨科

出　　处：《中国矫形外科杂志》2000年第7期669-671,728,共4页Orthopedic Journal of China

摘　　要：目的 :观察缓慢牵伸肢体延长后周围神经损伤的自然修复过程及结局。方法 :5 2只日本大耳白兔胫骨延长至 40 %后停止延长再分别继续观察 2周、4周、8周 ,观察各时相延长区胫后神经组织学改变。结果 :延长 40 %时 ,可见广泛的节段性脱髓鞘 ,朗飞氏结区增宽 ,且主要发生于大的有髓神经纤维。电镜下可见髓鞘呈双环状 ,空泡状改变及环形小体形成压迫轴突。并可见新形成的髓鞘。停止延长后随着时间的延长 ,这种改变逐渐修复。至 8周时基本恢复正常。结论 :缓慢牵伸下肢延长过程中周围神经的损害是可逆的 ,并可在短期内修复。Objective: The natural repairing process of peripheral nerves after tibial lengthening was studied by histological investigation to observe whether the histological damage of peripheral nerve was temporary or not.Methods:Histological changes were observed immediately,at 2 weeks,4 weeks and 8 weeks after 40% lengthening with light and electron microscopy.Results:Histological examination showed segmental demyelination which mainly occurred in big myelination fibers.Electron microscopy also showed new myelin Sheath formation at the Same time.These changes recovered gradually within 8 weeks.Conclusion:The subclinical damage of peripheral nerve during tibial lengthening is temporary and recoverable.

关 键 词：肢体延长 胫后神经 组织学 兔 周围神经损伤 

分 类 号：R651.3[医药卫生—外科学]