上海市新生儿乙肝疫苗持久性和加强免疫研究  

Study on Immune Persistence and Boost Vaccination of Hepatitis B Vaccine in Newborns Shanghai

作　　者：李燕婷[1] 袁国娟[1] 张家琪 施锦明 申惠国[4] 袁国平 吴寰宇[1] 沈荣明[1] 沈薇娟[1] 

机构地区：[1]上海市疾病预防控制中心,200031 [2]杨浦区疾病预防控制中心 [3]崇明县疾病预防控制中心 [4]闵行区疾病预防控制中心 [5]宝山区疾病预防控制中心

出　　处：《疾病监测》2000年第7期245-247,共3页Disease Surveillance

摘　　要：新生儿乙肝血源疫苗全程接种后 5～ 9年抗 -HBs阳性率和滴度 (MIU/ml)明显下降 ,约75%抗 -HBs水平在保护性水平 ( <10MIU/ml)以下。但乙肝表面抗原HBsAg阳性率与免疫后一年比较无明显差异 ,仍有很好保护效果。应用 5μg乙肝基因疫苗加强免疫一剂 ,再免后一个月抗 -HBs阳性率和滴度 (MIU/ml)明显升高 ,分别提高 2 8 60 %和 2 90倍 ,对抗 -HBsBoth the positive seroconversion rate and titer of anti HBs(mIU/ml) in the newborns who have been vaccinated with plasma derived hepatitis B vaccine in 1988～1992 have decreased markedly.About 75 percent of the newborns' antibody titer of anti-HBs was less than the protective titer level (<10 mIU/ml).But there was no significant difference in the positive seroconversion rate of HBsAg between pre-vaccination and one year after vaccination. It still has a good protective effect.After one month of vaccination with one dose (5μg) recombined yeast hepatitis B vaccine boost,the positive seroconversion rate and titer of anti-HBs have risen by 28.60% and 20.9% respectively.There was good recall reaction with boost vaccination in the children whose anti-HBs titer were less than 10 mIU/ml.

关 键 词：乙型肝炎疫苗 加强免疫 抗-HBS 上海市 新生儿 

分 类 号：R186[医药卫生—流行病学]