氟桂利嗪对青霉素致痫大鼠苯巴比妥钠脑组织药物浓度的影响  

Effect of flunarizine to the pharmacokinetics of phenobarbital sodium in epileptic rats induced by penicillin

作　　者：施弘[1] 孙晓江[1] 蒋青青[1] 姚继国[1] 

机构地区：[1]上海交通大学附属第六人民医院神经内科,上海200233

出　　处：《世界临床药物》2013年第12期735-737,746,共4页World Clinical Drug

摘　　要：目的研究氟桂利嗪对青霉素致痫大鼠苯巴比妥钠脑组织药物浓度的影响。方法 SD大鼠随机分成4组(n=10),A组为空白对照组注射生理盐水,B组注射苯巴比妥钠,C组注射氟桂利嗪,D组在B组的基础上联合氟桂利嗪。空白组及各给药组干预2 h后给予青霉素致痫,致痫30 min后处死并分离脑组织制备脑组织匀浆,HPLC测定苯巴比妥钠浓度。结果与B组相比,D组脑组织苯巴比妥钠浓度显著提高(P<0.05)。结论氟桂利嗪能提高苯巴比妥钠在致癫大鼠的脑组织药物浓度。Objective To investigate the effect of flunarizine to the pharmacokinetics of phenobarbital sodium in epileptic rats induced by penicillin. Methods A total of 40 rats were randomly divided into four groups, including blank control group（group A）, phenobarbital sodium（group B）, flunarizine（group C）and phenobarbital sodium plus flunarizine（group D）respectively.All rates were euthanized after 30 min of penicillin intravenous injection. Collected brain tissue and grinded into homogenate, and determine the concentration of phenobarbital sodium by HPLC. Results Compared with the group B, the phenobarbital sodium concentrations in brain homogenate of group D were increased significantly（P0.05）. Conclusion Flunarizine can enhance the phenobarbital sodium concentration in epileptic rats induced by penicillin.

关 键 词：氟桂利嗪 癫痫 苯巴比妥钠 

分 类 号：R971.6[医药卫生—药品]