天麻素缓释片对高危后循环短暂脑缺血发作患者外周Treg和IL-17的影响  

Influence of Gastrodin Sustained Release Tablets on CD_4^+ CD_(25)^+ Regulatory T Cells and Interleukin-17 in Patients with High-Risk Transient Ischemic Attack in Posterior Circulation

作　　者：杨汀[1] 樊光辉[2] 刁波[3] 

机构地区：[1]广州军区武汉总医院心血管内科,武汉430070 [2]广州军区武汉总医院院长办公室,武汉430070 [3]广州军区武汉总医院神经外科实验室,武汉430070

出　　处：《医药导报》2013年第12期1583-1586,共4页Herald of Medicine

基　　金：2010年度军队中医药科研专项课题(10ZYZ117)

摘　　要：目的探讨天麻素缓释片对高危后循环短暂脑缺血发作(TIA)患者外周CD4+CD25+调节性T细胞(Treg)比例及白细胞介素-17(IL-17)浓度的影响。方法将63例患者随机分为对照组(31例)和治疗组(32例),对照组采用拜阿司匹林肠溶片、阿托伐他汀钙片、注射用丹参多酚酸盐等常规治疗。治疗组在上述常规治疗的基础上加用天麻素缓释片,疗程均为28 d。应用流式细胞分析法及酶联免疫吸附法检测治疗前后患者外周Treg/(CD+4T)细胞比例及IL-17浓度的变化。结果治疗前,两组患者Treg/(CD+4T)细胞比例及IL-17浓度差异无统计学意义(P>0.05);治疗后,治疗组Treg/(CD+4T)细胞比例(15.30±2.97)高于对照组(13.48±2.58),差异有统计学意义(P<0.05),治疗组IL-17浓度(184.63±65.76)低于对照组(231.91±68.30),差异有统计学意义(P<0.05)。结论天麻素缓释片可能有助于改善高危后循环TIA患者的自身免疫炎症反应失衡。Objective To explore the influence of gastrodin sustained release tablets on CD4＋ CD25＋ regulatory T cells （Treg） and interleukin-17 （IL-17） in patients with high-risk transient ischemic attack（TIA） in posterior circulation. Methods Sixty-three patients with high-risk transient ischemic attack in posterior circulation were randomly divided into control group （n= 31 ） and experiment group （n = 32 ）. The control group was conventionally treated with aspirin enteric-coated tablets, atorvastatin calcium tablets and salvianolate injection and so on. The experiment group was treated with gastrodin sustained release tablets plus conventional therapy. Both groups were treated for 28 days before evaluation. The frequencies of Treg and the concentration of IL-17 in the peripheral blood were detected by flow cytometer and enzyme-linked immunoadsordent assay before and after the treatment. Results The frequencies of Treg and the concentration of IL-17 had no significant differences between the two groups before the treatment（ P〉0.05 ）. The frequencies of Treg were found to be significantly higher in experiment group （15.30±2.97） than in control group（13.48±2.58） （P〈0.05）, while the concentration of IL-17 was found to be significantly lower in experiment group（184.63±65.76） than in control group（231.91±68.30） （P〈0.05） after the treatment. Conclusion The gastrodin sustained release tablets may help to correct the imbalance in autoimmune inflammatory response in patients with high-risk TIA in posterior circulation.

关 键 词：天麻素 脑缺血发作 短暂 CD+4CD+25调节性T细胞 白细胞介素-17 动脉粥样硬化 自身免疫 

分 类 号：R285.5[医药卫生—中药学]