加替沙星治疗急性普通型伤寒22例  

Twenty-two Cases of Typhoid Fever Treated with Gatifloxacin

作　　者：吴华容[1] 明莫瑜[2] 黄翔[1] 

机构地区：[1]广西医科大学第四附属医院急诊科,柳州545005 [2]广西医科大学第四附属医院呼吸科,柳州545005

出　　处：《医药导报》2013年第12期1597-1599,共3页Herald of Medicine

摘　　要：目的 评估口服加替沙星治疗急性普通型伤寒的临床疗效和安全性.方法 急性普通型伤寒患者46例,采用随机对照方法分配至治疗组（22例）及对照组（24例）,治疗组给予加替沙星400 mg,po,qd,对照组给予静脉滴注左氧氟沙星400 mg,qd,连用14 d,比较两组痊愈率、有效率（中位退热时间及复发率）,评估两组药物的不良反应.结果 治疗组痊愈率、有效率分别81.8%和90.9%,对照组痊愈率、有效率分别为83.3%和91.7%（P＞0.05）;治疗组和对照组,中位退热时间分别为182.0（155.5～208.5）,162.1（136.6～187.6） h（P＞0.05）;治疗组和对照组复发率分别为9.1%,12.5%（P＞0.05）;药物不良反应发生率分别为9.1%,8.3%（P＞0.05）.结论 加替沙星疗效确切,可有效治疗伤寒沙门菌感染.Objective To evaluate the efficacy and safety of gatifloxacin in the treatment of ordinary type typhoid fever. Methods In the comparative study, patients were enrolled and randomized to two groups （test group and control group）. The patients received oral gatifloxaciu（ test group） or intravenous levofloxacin（ control group） 400 mg once daily for 14 days. Cure rate and clinical efficacy rate [ median （95% confidence interval） fever clearance time and relapse rate] were compared. The incidence of adverse reaction was evaluated. Results It showed that the cure rate and clinical efficacy rate in the test group were 81.8% and 90.9% in the test group, and 83.3% and 91.7% in the control group, respectively（ P〉0.05 ）. The median （95% confidence interval） fever clearance time of gatifloxacin and levofloxacin were 182.0（155.5-208.5） hours and 162.1 （136.6-187.6） hours, respectively（P〉0. 05）. The relapse rate in the test and control group was 9. 1% and 12.5%, respectively（ P〉0.05 ）. The incidence of adverse reaction in the test and control group was 9.1% and 8.3% , respectively （P〉 0.05 ）. Conclusion Gatifloxacin has an excellent clinical efficacy and good safety profile in treating patients with ordinary type typhoid fever.

关 键 词：加替沙星 左氧氟沙星 伤寒 普通型 急性 

分 类 号：R979.9[医药卫生—药品] R254.1[医药卫生—药学]