Synthesis and Characterization of Chitosan-graft-Poly(lactic acid) Copolymer  

作　　者：牛旭锋 Feng Tian Li-zhen Wang Xiao-ming Li Gang Zhou 樊瑜波 

机构地区：[1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University [2]BUAA Research Institute

出　　处：《Chinese Journal of Polymer Science》2014年第1期43-50,共8页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.11272038,50803032,11032012,10925208,11202017 and 11120101001);the Fundamental Research Funds for the Central Universities(No.YWF-13-T-RSC-024);the 111 Project(No.B13003);the International Joint Research Center of Aerospace Biotechnology and Medical Engineering,Ministry of Science and Technology of China;the Program of Pearl River Young Talents of Science and Technology in Guangzhou,China(No.2013Z2200010)

摘　　要：Chitosan-graft-poly（lactic acid） （CS-g-PLA） copolymer was synthesized through emulsion self-assembly in a water-in-oil （W/O） microemulsion. The water phase was composed of CS aqueous solution, while the oil phase was made up of PLA in chloroform. The W/O microemulsion was fabricated in the presence of surfactant span-80 and the self-assembly was performed between PLA and CS under the effect of N-（3-dimethylaminopropyl）-N＇ethylcarbodiimide hydrochloride （EDC＇HCI）. FTIR and IH-NMR analysis indicated PLA was grafted onto the backbone of CS via the reaction between the carboxyl groups in PLA and the amino groups in CS. 1H-NMR characterization further revealed the grafting content of PLA was 16%. The obtained CS-g-PLA could self-assemble to form micelles, their size distributed in the range of 125-375 nm with average diameter of 142 nm. The present design integrates the favorable biological properties of CS and the excellent mechanical properties of PLA, which makes CS-g-PLA copolymer a promising candidate as a carrier for targeted bioactive molecules delivery.Chitosan-graft-poly（lactic acid） （CS-g-PLA） copolymer was synthesized through emulsion self-assembly in a water-in-oil （W/O） microemulsion. The water phase was composed of CS aqueous solution, while the oil phase was made up of PLA in chloroform. The W/O microemulsion was fabricated in the presence of surfactant span-80 and the self-assembly was performed between PLA and CS under the effect of N-（3-dimethylaminopropyl）-N＇ethylcarbodiimide hydrochloride （EDC＇HCI）. FTIR and IH-NMR analysis indicated PLA was grafted onto the backbone of CS via the reaction between the carboxyl groups in PLA and the amino groups in CS. 1H-NMR characterization further revealed the grafting content of PLA was 16%. The obtained CS-g-PLA could self-assemble to form micelles, their size distributed in the range of 125-375 nm with average diameter of 142 nm. The present design integrates the favorable biological properties of CS and the excellent mechanical properties of PLA, which makes CS-g-PLA copolymer a promising candidate as a carrier for targeted bioactive molecules delivery.

关 键 词：Poly（lactic acid） CHITOSAN COPOLYMER SELF-ASSEMBLING Grafting. 

分 类 号：TQ321.2[化学工程—合成树脂塑料工业]