229例低复制慢性乙型肝炎患者血清相关指标的分析  

Analysis and application of 229 cases of low replication in patients with chronic hepatitis B related indicators

作　　者：许文龙[1] 李祥云[2] 夏大静[1] 

机构地区：[1]浙江大学医学院感染与免疫中心,浙江杭州310058 [2]杭州师范大学附属医院检验科,浙江杭州310015

出　　处：《中国微生态学杂志》2013年第12期1397-1400,共4页Chinese Journal of Microecology

基　　金：杭州市医药卫生科技计划项目(20100633B17)

摘　　要：目的探讨血清HBV-DNA低复制的CHB患者相关指标的变化及意义。方法收集HBV-DNA低复制的CHB患者血液标本229例,ALT、乙肝标志物、mIL-2R、IL-10、miRNA-122等指标均采用全自动分析仪测定,对结果进行比较和线性相关分析。结果低复制CHB患者中e抗原阳性患者占38.00%,e抗原阴性患者占51.53%;229例患者ALT升高者占总数的66.81%,患者血浆miRNA-122的表达量的变化与ALT浓度呈正相关(r=0.841)。e抗原阳性与e抗原阴性组IL-10、mIL-2R浓度与对照组比较差异均有统计学意义(P<0.05)。结论 HBV-DNA低复制CHB患者ALT、mIL-2R、IL-10、miRNA-122等指标的变化证明此类患者部分病例存在肝细胞实质性的损害,临床应高度重视,尤其要与非活动性乙型肝炎病原携带状态相鉴别,不可一概而论。Objective To study the changes and significance of chronic hepatitis B（CHB） in patients with serum HBV-DNA low replication index. Methods 229 cases of blood specimens from patients with CHB collected HBV- DNA low copy, ALT, HBV markers, mIL-2R, IL-10, miRNA-122 and other indicators were used automatic analyzer, and compared to the linear correlation analysis on the results. Results 38% of patients with HBeAg positive low copy CHB patients, HBeAb positive patients accounted for 51.53% ; 229 cases of patients with ALT ele- vated in 66. 81% of the total, changes in expression levels of plasma of miRNA-122 patients was positively correlated with ALT （r = 0. 841 ）. HBeAg positive and HBeAg negitive groups of IL-10 and mIL-2R concentrations compared with the control group had significant difference （P 〈 0. 05 ）. Conclusion Changes of HBV-DNA low copy CHB in patients with ALT, mIL-2R, IL-10, miRNA-122 and other indicators that some of these patients have the substantive liver cell damage, clinical attention should he paid to.

关 键 词：慢性乙型肝炎 低复制 膜白细胞介素-2受体 白细胞介素10 micro-RNA-122 

分 类 号：R512.62[医药卫生—内科学]