黄芩茎叶总黄酮对脑组织缺氧的保护作用  

THE PROTECTION OF TOTAL FLAVONID FROM STEMS AND LEAVELS OF SCUTELLARIA BAICAL ENSIS AGAINST BRAIN ANOXIA

作　　者：李素婷[1] 王宝元[2] 杨鹤梅[1] 王鲁华[1] 曹凯[1] 

机构地区：[1]承德医学院生化教研室,河北承德067000 [2]承德医学院附属肛肠医院

出　　处：《承德医学院学报》2000年第3期23-25,共3页Journal of Chengde Medical University

摘　　要：目的 :研究黄芩茎叶总黄酮 (TF)对脑组织缺氧的保护作用。方法 :小鼠脑缺氧模型采用断头制备。过氧化脂质 (LPO)采用改良 TBA法测定 ,谷胱甘肽过氧化物酶 (GSH- PX)活力采用化学比色法测定。结果 :黄芩茎叶总黄酮 2 0 0、40 0、80 0 mg· kg- 1显著延长小鼠断头后喘息持续时间 ,降低脑组织 LPO的含量 ,提高 GSH- PX活力 ,且呈一定的量效关系。结论 :黄芩茎叶总黄酮对脑组织缺氧有显著保护作用 ,其作用可能与抑制膜脂质过氧化物的含量和提高GSH-Objective:To study the protection of TF against brain anoxia.Methods:Mice were give different dosage by way of ig for there weeks,Three weeks later,we made model of brain anoxia of mice and determined the glutahion proxidase(GSH PX) activity and the lipid peroxide(LPO) content in the brain homogenates.Results:Compared with the contral group,TF markedly prolonged the breathing time after mice being headed,increased the activity of GSH PX and decreased the LPO content in the brain homogenates.Conclusion:the protection of TF against train anoxia is related to increasing activity of GSH PX and decreasing content of LPO.

关 键 词：黄芩 总黄酮 过氧化脂质 中药 药理 

分 类 号：R282.710.5[医药卫生—中药学]