新生儿坏死性小肠结肠炎危险因素研究  

Analysis of risk factors associated with neonatal necrotizing enterocolitis

作　　者：王瑞芹[1] 郑冬凌 赵晓忠[1] 柴昶红[1] 

机构地区：[1]黑龙江省大庆龙南医院儿科,黑龙江大庆163453 [2]黑龙江省大庆市卫生技术学校

出　　处：《中国妇幼保健》2014年第2期225-227,共3页Maternal and Child Health Care of China

摘　　要：目的:对新生儿坏死性小肠结肠炎(NEC)的相关危险因素进行分析,以期为新生儿NEC的预防提供参考。方法:对2009年9月～2013年6月该院接诊的NEC患儿(实验组)38例和非NEC患儿(对照组)42例的病例资料进行回顾性分析,包括母亲因素、产时因素、新生儿一般资料、NEC发病前患儿情况等因素,对上述因素进行单因素和多因素分析,从而得出新生儿NEC的危险因素。结果:两组患儿胎龄和出生体重差异不具有统计学意义(P<0.05)。单因素分析显示,实验组患儿在产前糖皮质激素使用、产时窒息、发病前出现呼吸衰竭、感染肺炎、出生后吸氧、感染性休克、败血症、低钠血症和低钙血症、发病前喂养以及发病前口服益生菌等11个因素的比例与对照组的差异具有统计学意义(P<0.05)。多因素Logistic回归分析显示,NEC的发生与肺炎、败血症、发病前喂养和口服益生菌相关。结论:肺炎、败血症、发病前喂养和口服益生菌与NEC的发生直接关联,这对以后临床预防新生儿NEC具有一定的借鉴意义。Objective： To analyze the risk factors associated with neonatal necrotizing enterocolitis （NEC）, in order to provide a reference for the prevention of the disease. Methods： 38 cases with NEC （experimental group） and 42 cases non- NEC （control group） in our hospital from September 2009 to June 2013 were collected, clinical data were retrospectively analyzed, including maternal factors, in- trapartum factors , neonatal general information, and other onset in children before NEC, univariate and multivariate analysis of the above factors were conducted, in order to identify the risk factor for neonatal NEC. Results： The difference of gestational age and birth weight of children in two groups was not statistically significant （ P 〈 0. 05 ） . Univariate analysis showed that such 11 factors including antenatal glu- eoeorticoid use, intrapartum asphyxia, respiratory failure before onset, pneumonia, oxygen after birth, septic shock, sepsis, hyponatrem- ia, hypocaleemia, feeding and oral probioties before onset in the experimental group had a proportion greater than in the control group, and the differences were statistically significant （ P 〈 0. 05 ） . Logistic regression analysis Showed that, NEC occurrence related to pneumonia, sepsis, feeding and oral probiotics before onset. Conclusion： Pneumonia, sepsis, feeding and oral probiotics before onset are directly cor- related with the incidence of NEC, which is of certain significance in subsequent clinical prevention of neonatal NEC.

关 键 词：新生儿坏死性小肠结肠炎 危险因素 LOGISTIC 回归分析 

分 类 号：R722.1[医药卫生—儿科]