巨噬细胞在动脉粥样硬化中的研究进展  

Research Progress of the Roles of Macrophages in Atherosclerosis

作　　者：阎雨[1] 何阳阳[1] 方莲花[1] 杜冠华[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京市药物靶点研究与新药筛选重点实验室,北京100050

出　　处：《中国药学杂志》2014年第1期7-10,共4页Chinese Pharmaceutical Journal

基　　金：“重大新药创制”科技重大专项(2013ZX09103-001-008,2012ZX09103-101-078);国际科技合作专项项目(2011DFR31240)

摘　　要：目的综述巨噬细胞在动脉粥样硬化病程中的主要作用,为动脉粥样硬化的诊断、治疗及药物研究和开发提供文献依据和新的策略。方法对近几年关于巨噬细胞在动脉粥样硬化中作用的文献进行查阅、分析、归纳和总结。结果与结论巨噬细胞参与了动脉粥样硬化病理进程中的多个环节,巨噬细胞相关细胞因子、趋化因子、酶、转运蛋白、miRNA等生物大分子发挥着重要作用。认识巨噬细胞及相关生物大分子在动脉粥样硬化发生发展中的作用,对于深入理解动脉粥样硬化的病因、发病机制,为其提供诊断、治疗及药物研发依据具有重要意义。OBJECTIVE To review the central functions of macrophages in atherosclerosis, to provide the literature support and strategies for diagnosis, therapy, pharmaceutical research and development of atherosclerosis. METHODS This paper had consulted, analysed, concluded and summarized research progress of the functions of maerophages in atheroselerosis in recent years. RESULTS AND CONCLUSION Macrophages participate in many stages of atheroselerosis, and biomacromoleeules related to maerophages, such as eytokines, ehemokines, enzymes, transportproteins and miRNA, also play important roles. It is important to recognize the roles of mac- rophages and related biomaeromoleeules in atherosclerosis development in order to deeply understand etiology and pathogenesis of athero- sclerosis, and provide bases for diagnosis, therapy, pharmaceutical research and development.

关 键 词：动脉粥样硬化 巨噬细胞 炎症 药物研发 

分 类 号：R95[医药卫生—药学]