硫酸头孢噻利小鼠脑内药动学研究  

Pharmacokinetic Profile of Cefoselis Sulfate in Mice Brain

作　　者：朱延焱[1] 平丽[2] 田伟强[1] 

机构地区：[1]丽水市中心医院临床药学室,浙江丽水323000 [2]浙江大学药物安全评价研究中心,杭州310058

出　　处：《中国药学杂志》2014年第1期61-63,共3页Chinese Pharmaceutical Journal

基　　金：浙江省医学会临床科研基金项目(2011ZYC-A120)

摘　　要：目的研究硫酸头孢噻利在小鼠脑内药动学特征。方法小鼠单次尾静脉注射头孢噻利后,不同时间点取小鼠脑组织并以HPLC测定脑内药物含量,采用DAS3.1软件处理,计算药动学参数并进行统计学分析。结果小鼠脑中硫酸头孢噻利的主要药动学参数t1/2为0.261 h,c max18.728μg·g-1,AUC0-t10.119μg·h·g-1,MRT0-t1.945 h。结论小鼠单次尾静脉注射硫酸头孢噻利后,在脑内分布快,呈一室模型,提示硫酸头孢噻利外周静脉给药能有效的治疗细菌引起的颅内感染。OBJECTIVE To study pharmacokinetic profile of cefoselis sulfate in mice brain. METHODS Brain samples were collected at different time points after caudal vein administration of eefoselis sulfate at single bolus dose, HPLC methods were validated to analysis drug concertations, and pharmaeokinetie parameters were calculated by professional software named DAS3.1 pharmacokinetic program. RESULTS The main pbarmacokinetic parameters of cefoselis sulfate in mice brain was about： t1/2 0. 261 h, c 18. 728μg·g-1, AUC0-t 10. 119 μg·h·g-1, and MRT0_, 1. 945 h. CONCLUSION The distribution of cefoselis sulfate is extremely fast in mice brain after administration, appeared to best fit the kinetics of a one-compartment model, the results indicate that cefoselis sulfate viaperipheralintravenous admininstraion is efficacy to theraphy the intracranial infection.

关 键 词：硫酸头孢噻利 脑组织 药动学 

分 类 号：R285[医药卫生—中药学]