不同煎煮方法黄连阿胶汤对口腔溃疡大鼠的影响  

Effects of Huanglian Ejiao Decoction with Different Decoction Methods on Mouth Ulcer Rats

作　　者：李凯[1] 贾利利[1] 李赫宇 张振凌[1] 

机构地区：[1]河南中医学院药学院,河南郑州450008 [2]天津市益倍建生物技术有限公司,天津300457

出　　处：《中华中医药学刊》2014年第1期41-42,I0001,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药行业科研专项项目(201007010);河南中医学院博士基金项目(BSJJ2010-06)

摘　　要：目的:研究不同煎煮方法黄连阿胶汤对口腔溃疡模型大鼠作用的差异。方法:将SD大鼠分为空白对照组、口腔溃疡模型组、口炎清组、黄连阿胶汤传统煎煮、机械常压、机械高压组,选用甲状腺和苯酚综合造模阴虚型口腔溃疡,取大鼠全血分离血清,采用酶免法测定三碘甲状腺原氨酸(T3)、甲状腺素(T4)、肿瘤坏死因子(TNF-α)和血管内皮生长因子(VEGF)含量。结果:黄连阿胶汤模型组与对照组之间T3、T4具有显著升高(P<0.01);TNF-α、VEGF具有显著性差异(P<0.01);传统煎煮组、机械常压组、机械高压组之间T3、T4、TNF-α、VEGF含量没有显著性差异(P>0.05)。结论:黄连阿胶汤对阴虚口腔溃疡大鼠有治疗作用,但不同煎煮方法样品治疗作用无显著差异。Objective：To study the effects of Huanglian Ejiao Decoction with different decoction methods on mouth ulcer rats. Methods：SD rats were divided into blank control group, mouth ulcer model group, Kouyanqing group and Huanglian Ejiao Decoction traditional decoction group, mechanical atmospheric pressure group, mechanical high -pressure group. The rat model was created by thyroxine and phenol. Contents of triiodothyronine （T3）, thyroxine （T4）, tumor necrosis factor（ TNF - α） and vascular endothelial growth factor（VEGF） were measured and compared. Results：Compared to blank group,contents of T3 and T4 were higher in mouth ulcer group （P 〈0.01 ）. TNF - α and VEGF had significant difference （P 〈 0.01 ）. Traditional decoction group,mechanical atmospheric pressure group and mechanical high- pressure group had no significant difference （P 〉0. 05）. Conclusion：Huanglian Ejiao Decoction was effective to mouth ulcer, and different decoction methods had no significant difference.

关 键 词：黄连阿胶汤 口腔溃疡 传统煎煮 机械常压煎煮 机械高压煎煮 

分 类 号：R285.5[医药卫生—中药学]