经颅彩色多普勒测定大脑中动脉血流量的应用  

Application for noninvasive measuration of cerebral blood flow volume with transcranial color Doppler energy

作　　者：康维强 郝恩魁 刘济英[2] 吕晓兰 于义英 孙吉辉 孙青 吕洪财 

机构地区：[1]青岛市海慈医疗集团青岛市心血管病研究所,266033 [2]青岛市人民医院超声科

出　　处：《中华超声影像学杂志》2000年第10期599-602,共4页Chinese Journal of Ultrasonography

摘　　要：目的　探讨多普勒超声无创性定量检测脑血流量 (CBFV)的应用价值。方法　采用多普勒超声联合磁共振血管成像 (MRA)技术对 78例正常人 (A组 )和 49例脑血管病患者 (B组 )的大脑中动脉(MCA)进行CBFV测量 ,并与133Xe吸入法测定结果比较。采用经颅多普勒超声 (TCD)和彩色多普勒能量图 (CDE)技术测量平均血流速度 (Vm) ,以CDE和MRA测量血管面积 ,CBFV (ml/min) =(D/ 2 ) 2 ·π·Vm·6 0。结果　TCD和CDE测量的Vm 均数间差异有显著性意义 (P <0 .0 1) ,前者明显低估CDE测值 ;CDE测量的血流束内径与MRA的血管面积测值在A、B两组高度相关 (r =0 .93 ,0 .90 ) ;CDE测量的CBFV在A组中右侧 (5 0 8.7± 71.7)ml/min ,左侧 (5 2 6 .6± 73 .2 )ml/min ;B组为 (4 4 7.1± 96 .7)ml/min ;TCD +MRA、TCD +CDE、CDE +MRA和CDE 4种技术测量CBFV的指标中 ,后二者与133Xe吸入法的相关最佳(r =0 .89,0 .88,P <0 .0 1)。B组中CBFV在不同流速中的测值与133Xe吸入法测定结果高度相关 (r =0 .86～ 0 .89,P <0 .0 1)。结论　采用CDE和TCD联合MRA技术是一种可靠的非侵入性测定CBFV的方法 。Objective To develop a new reliable method for noninvasive quantitative measuring the cerebral blood flow volume(CBFV) in normal subjects and patients with cerebral arteries diseases.Methods The middle cerebral artery(MCA) of 78 normal subjects(group A) and 49 patients with cerebral infarct(group B) were studied by transcranial Doppler(TCD)、transcranial color Doppler energy(CDE), magnetic resonance angiography(MRA) and 133 Xe inhalation method. CBFV equal to: CBFV (ml/min) = (D/2) 2·π·V m·60.Results ①V m of MCA with TCD and CDE were significantly difference, TCD significantly underestimated (P< 0.01 ). ②The vessels area both group A and B were a high correlation between TCDE and MRA(r= 0.93 and 0.90 ,P< 0.01 ); ③Normal CBFV of the right side studies at ( 508.7 ± 71.7 )ml/min, while left side ( 526.6 ± 73.2 )ml/min, there was a high correlation between CDE and 133 Xe(r= 0.86 ～ 0.90 ), both CDE+MRA and CDE correlated well with 133 Xe(r =0.89 and 0.88 , respectively);④CBFV of group B was ( 447.1 ± 96.7 )ml/min and agreed highly with 133 Xe(r= 0.86 ～ 0.89 ).Conclusions CDE and TCD with MRA is a accurate and reliable method to measure CBFV noninvasively and can be used to evaluate cerebral hemodynamics chages and different degrees of cerebral arteriopathy in patients with cerebral infarction also.

关 键 词：超声检查 经颅多普勒 脑动脉 血流量 应用 

分 类 号：R445.1[医药卫生—影像医学与核医学]