几种脑组织注射液药理作用的比较研究  

Comparative Study on Pharmacological Effects of Several Creatural B rain Derived Peptide Injections

作　　者：刘维俊[1] 陈海松[1] 叶小青[1] 许春琴[1] 郑霞[1] 

机构地区：[1]海南省药品检验所药理室,海口570102

出　　处：《中国生化药物杂志》2000年第5期223-226,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 :对国产和进口的脑组织注射液的药理作用进行比较。方法 :采用断头、结扎双侧带迷走神经颈总动脉、结扎双侧颈总动脉致动物脑急性缺氧缺血 ,测定动物张口喘息时间、脑血管通透性、脑指数、脑含水量、血清中磷酸肌酸激酶和乳酸脱氢酶水平 ;测定由东莨菪碱、NaNO2 及乙醇致记忆障碍小鼠的错误潜伏期和错误次数。结果 :国产和进口脑组织注射液均能显著延长小鼠断头张口喘息时间和结扎双侧带迷走神经颈总动脉小鼠的存活时间 ;对结扎大鼠双侧颈总动脉引起的脑血管通透性、脑指数和脑含水量的增高以及血清中磷酸肌酸激酶和乳酸脱氢酶水平的升高等均有明显的抑制作用 ;可显著抑制由东莨菪碱、NaNO2 及乙醇致记忆障碍小鼠的错误潜伏期和错误次数。结论Purpose:The aim is to compare the pharmacological e ff ects of Cerebrolysin, Naoduotai (Cerebral polypeptide) injection(NDT) and Naozuz hi(Cerebral tis sue) injection (NZZ).Methods:Acute cerebral ischemia was produced by beheadne ss and by close normobaric hypoxia in mice, acute cerebral ischemia was produced by ligating both bilateral carotid arteries and pneumogastric nerves in mice, a nd it was produced by ligating bilateral carotid arteries in rats.Hypomnesia was p roduced by exposure to ig ethanol or sc NaNO 2 or ip myoscine methabromide.Results:Cerebrolysin,NDT and NZZ markedly delayed the death time of mice that had beheadness,and ligating both bilateral carotid arteries and pneumogast ric nerves.Cerebrolysin, NDT and NZZ markedly inhibited the exponent and water w e ight of brain and the change of CPK and LDH in serum in rats that had ligating b ilateral carotid arteries,it inhibited the oxygen carrying capacity of blood pas sing through the blood vessel.Cerebrolysin,NDT and NZZ markedly inhibited error times and error delitescence by exposure to ig ethanol or sc NaNO 2 or ip myosc ine methabromide in mice.Conclusion:The pharmacological effects of t he cerebrolysin and pharmacological effects of the NDT and NZZ were similar.

关 键 词：脑多肽注射液 脑组织注射液 脑缺血 药理 

分 类 号：R392－33[医药卫生—免疫学] R944.11[医药卫生—基础医学]