活血潜阳方降压作用及其对高血压病血栓前状态影响的临床研究  

Antihypertensive effect of“Huoxue Qianyang Formula”on prothrombotic state in patients with hypertension

作　　者：肖梅芳[1] 赵国定[1] 周端[2] 曹敏[2] 李威[1] 钱文[1] 毛伟珍 

机构地区：[1]上海市黄浦区中心医院心内科,上海200002 [2]上海中医药大学附属龙华医院心内科,上海200032

出　　处：《上海中医药杂志》2013年第12期46-49,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市卫生局资助项目(2005L013A)

摘　　要：目的观察活血潜阳方的降压作用及其对高血压患者血栓前状态的影响。方法将99例血瘀阳亢型高血压病例随机分为治疗A组(予以活血潜阳中药方治疗)、治疗B组(予以苯磺酸氨氯地平片加活血潜阳中药方联合治疗)及对照组(予以苯磺酸氨氯地平片治疗),每组33例。各组疗程均为8周,观察患者治疗前后血压、中医证候积分及血浆血管性血友病因子(vWF)、D二聚体(DD)、纤维蛋白原(Fig)指标水平的变化情况。结果①治疗8周后,共有96例患者完成临床观察,治疗A组31例,治疗B组32例,对照组33例。②治疗前分别与治疗第28天、第56天比较,3组组内收缩压、舒张压、中医证候积分水平差异均有统计学意义(P<0.05);而各组治疗第28天、第56天组内比较,收缩压、舒张压、中医证候积分水平差异均无统计学意义(P>0.05)。两治疗组分别与对照组治疗第28天、第56天比较,收缩压、舒张压、中医证候积分水平差异均有统计学意义(P<0.05);而两治疗组间治疗第28天、第56天分别比较,收缩压、舒张压、中医证候积分水平差异均有统计学意义,治疗B组优于治疗A组(P<0.05)。③治疗前与治疗第56天比较,各组组内vWF、DD、Fig水平差异均有统计学意义(P<0.05)。两治疗组分别与对照组治疗第56天比较,vWF、DD、Fig水平差异均有统计学意义(P<0.05);两治疗组间治疗第56天比较,vWF、DD、Fig水平差异均有统计学意义,治疗B组优于治疗A组(P<0.05)。结论活血潜阳方联合苯磺酸氨氯地平治疗血瘀阳亢型高血压,可明显降低血压、缓解患者临床症状、改善血栓前状态。Objective To invcsligate the antihypertensive effect of ＂ Huoxue Qianyang Formula＂ on prothrumhotic state （PTS） in patients with hyperlensimL Methods Ninty-ninc cases with hypertension of hlood stasis and yang hyperactivity pattern were randomized into group A （ treated with Chinese medicine）, group B （treated wilh Amlodipine Tablet and Chinese medicine）, control group （treated with Amlodipiue Tablet）, with 33 cases in each group, with the course of 8 weeks. The blood pressure, clinical symptoms and levels of blood plasma vWF, DI） and Fig were ohserved. Results ①After 8 weeks treatment, 96 cases were finished this clinical observation. Thirty-one cases in group A, 32 cases in group B and 33 cases in control group. ② There were significant differences in systolic pressure, diastolic pressure and （linical symptoms among the three groups between before treatment and 28th day after treatment or between before treatment and 56th day after treatment （ P 〈 0.05 ）. On the 28th day and 56th day, no significant dift）rence was fimnd in systolic pressure, diastolic pressure and clinical symptoms among the groups （ P 〉 0.05）. After treatmcnt, there were significant differnees in systolic pressure, diastolic pressure and clinical symptoms between treatment groups and control group at the 28th day and 56th day （P 〈 0. 05 ）. there were significant differences in systolic pressure, diastolic pressure and clinical symptoms between the two treatment groups at the 28th day and 56th day after treatmcnt respectively, and the therapeutic effect of group B was better than the group A （ P 〈 0.05 ）. ③ The levels of vWF, DD and Fig before treatment were different from that of the 56th （lay after treatment among the three groups （P 〈0.05 ） ; al the 56th day, there were significant difference in the levels of vWF, DD and Fig between treatment groups and control group （P 〈 0. 05 ） ; significant differences were found in the levels of vWF, DD and Fig between the two Ireatmen

关 键 词：高血压 活血潜阳方 阳亢血瘀 血栓前状态 临床研究 

分 类 号：R544.1[医药卫生—心血管疾病]