2型糖尿病家系一级亲属血脂分析  

Analysis on blood lipid of first degree relatives of type 2 diabetes

作　　者：张丽锋[1] 张樨[1] 

机构地区：[1]福建省级机关医院老年病研究室,福州350003

出　　处：《福建医药杂志》2013年第6期16-18,共3页Fujian Medical Journal

基　　金：福建省卫生厅青年科研课题(2008-2-8)

摘　　要：目的研究2型糖尿病家系一级亲属血脂的变化规律。方法以37个2型糖尿病家系中的一级亲属(n=98)为受试者,按照OGTT结果分为3组:糖耐量正常(NGT)组(n=61)、糖调节受损(IGR)组(n=22)和糖尿病(DM)组(n=15),并以正常体检者为对照组(n=39)。分别检测及比较各组血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平。结果 3个受试组TG水平均高于对照组(NGT组、IGR组与对照组比较,均P<0.05;DM组与对照组比较,P<0.01),而TC、LDL-C及HDL-C水平的差异均无统计学意义。结论 2型糖尿病家系一级亲属血脂代谢紊乱,主要表现为TG升高。Objective To investigate the changes of blood lipid levels in first degree relatives of type 2 diabetes. Methods A total of 98 first degree relatives were divided into three groups according to the result of oral glucose test （OGTT）, including normal glucose tolerance group （61 cases）, impaired glucose regulation group （22 cases） and diabetes group （15 cases）. Thirtynine healthy adults were acted as control. The levels of total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C） and high-density lipoprotein cholesterol （HDL-C） were detected and compared between the three experimental groups and control group. Results The level of TG in three experimental groups was higher than that in control group, respectively （P〈0.05 or P〈0.01）. There was no statistical difference in the levels of TC, LDL-C and HDL-C between experimental groups and control group. Conclusion The higher TG level is main dyslipidemia in first degree relatives of type 2 diabetes.

关 键 词：2型糖尿病 一级亲属 血脂 三酰甘油 

分 类 号：R587.1[医药卫生—内分泌]