钙激活的大电导钾离子通道在成年斑胸草雀脑中的分布  

Ca^(2+)-activated K^+ channels of the BK-type in the brain of adult male zebra finches

作　　者：李东风[1] 李鸿谷[1] 宋吉峰 

机构地区：[1]华南师范大学生命科学学院,广东广州510631

出　　处：《辽宁师范大学学报（自然科学版）》2013年第4期534-538,共5页Journal of Liaoning Normal University:Natural Science Edition

基　　金：国家自然科学基金项目(31172092)

摘　　要：BK通道,即钙离子激活的大电导钾离子通道,它通过产生快速的后超极化(fAHP)来控制动作电位的持续时间、发放频率.为研究BK通道在鸣禽鸣唱学习中的作用提供形态学依据,用免疫组化法观察了BK通道在成年雄性斑胸草雀脑中的分布.证实了其在端脑、基底节纹状体、中脑、小脑等脑区都有广泛的表达,其中RA、HVC、LMAN、X区、DM等与鸣唱系统相关的核团都有显著的表达.这暗示了BK通道可能与鸣禽鸣唱信息整合、听觉反馈、鸣曲可塑性和稳定性以及呼吸调节都有密不可分的联系.BK channels ,large conductance calcium activated potassium channels ,w hich can generate fast after-hyperpolarization （fAHP） ,to control the duration and firing frequency of action potentials . To provide morphological basis for studying the role of BK channels in songbird vocal learning ,distri-bution of BK channels in the adult male zebra finches brain were observed with immunohistochemical method .The results showed that BK channels have a wide range of expression in the telencephalon , midbrain ,cerebellum ,basal ganglia striatum and other brain regions ,including RA ,HVC ,LM AN ,X , DM and other related song nuclei .The results suggested that BK channel may be related to voice in-formation integration ,auditory feedback ,song plasticity and stability as well as the regulation of res-piration .

关 键 词：斑胸草雀 BK通道 鸣唱相关核团 免疫组织化学 

分 类 号：Q955[生物学—动物学]