噬菌体治疗细菌感染的研究进展  

Research advance on bacteriophage therapy in bacterial infection

作　　者：裴景亮[1] 付玉荣[2] 

机构地区：[1]潍坊医学院医学检验学系,附属医院检验科,山东省临床检验诊断学高校重点实验室,山东潍坊261031 [2]潍坊医学院基础医学院病原生物学教研室,山东潍坊261053

出　　处：《浙江大学学报（医学版）》2013年第6期700-704,共5页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金资助项目(81100006);山东省自然科学基金资助项目(ZR2010HM073)

摘　　要：噬菌体是一种细菌依赖性病毒,在治疗细菌特别是耐药性细菌感染方面,与传统的抗生素比较具有独特的优势,其代谢动力学及给药途径是目前的研究热点。噬菌体裂解酶作为一种新的治疗手段,具有比活性噬菌体制剂更多的优点。文中就噬菌体在细菌感染治疗方面的作用机理、给药途径和基因工程的应用,及噬菌体裂解素的研究进展进行综述,对噬菌体治疗细菌感染提出展望。] Bacteriophage is a bacterium dependent virus. It has unique advantages in the treatment of bacterial infection, especially infection caused by drug-resistant bacteria. Its metabolic kinetics and route of administration are the current research focus. Bacteriophage lytic enzyme, as a new therapeutic method, has more advantages than active bacteriophage. This review is focused on the recent progress in bacteriophage research, including the mechanism of bacteria lysis, the route of administration, the application of genetic engineering, etc.

关 键 词：细菌噬菌体 裂解酶 给药途径 细菌感染 治疗 

分 类 号：R515[医药卫生—内科学]