氯胺酮分别联合异丙嗪、戊巴比妥钠和水合氯醛药物用于兔麻醉效果的比较与评价  

Anesthetic effects of ketamine combined with promethazine,pentobarbital sodium and chloral hydrate in rabbits: Comparison and assessment

作　　者：张银[1] 高莹[1] 黄锦[1] 双金权[1] 范志宁[1] 

机构地区：[1]南京医科大学第二附属医院消化医学中心,南京医学硕士研究生210011

出　　处：《医学研究生学报》2013年第12期1241-1243,共3页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81172266);江苏省自然科学基金(BK2011859)

摘　　要：目的用兔构建动物模型来模拟疾病的发生发展和治疗已应用在很多实验中,而稳定的动物麻醉是其中重要的一部分。本实验评价氯胺酮联合异丙嗪、戊巴比妥钠和水合氯醛这3组药物对兔的麻醉效果。方法根据麻醉药的不同将兔分为氯胺酮联合异丙嗪组、戊巴比妥钠组和水合氯醛组,分别对兔行腹腔麻醉。观察药物对兔的麻醉诱导时间、麻醉维持时间以及死亡率的影响。结果氯胺酮联合异丙嗪组兔的死亡率最高、水合氯醛组最低,水合氯醛组兔未死亡麻醉良好率最高。结论兔实验中应用水合氯醛为麻醉药是最安全有效的。Objective Rabbit models are used in various experiments, and stable animal anesthesia plays a critical part. This study was to assess the anesthetic effect of ketamine combined with promethazine, pentobarbital sodium and chloral hydrate in rab- bits. Methods Totally, 180 rabbits were randomly assigned to 3 groups to be anesthetized with ketamine in combination with promethazine, pentobarbital sodium and chloral hydrate, respectively. Then we obtained such indexes as breathing rate, heart rate, eyelash reflex, duration of anesthesia, death rate and so on. Results The death rate was 16.7% in the promethazine group, 3.3% in the pentobarbital group and 0% in the chloral hydrate group. Conclusion Chloral hydrate is a safe and effective anesthetic agent in rabbits.

关 键 词：兔 麻醉 氯胺酮 异丙嗪 戊巴比妥钠 水合氯醛 

分 类 号：R971.2[医药卫生—药品]