先天性白内障大鼠的繁殖性能及其生长发育  

Reproductive performance,growth and development of rats with congenital cataract

作　　者：田小芸[1] 尤金炜[1] 董敏[1] 许龙祥[1] 赵志刚[1] 方天[1] 恽时锋[1] 

机构地区：[1]南京军区南京总医院比较医学科,南京210002

出　　处：《中国比较医学杂志》2013年第12期10-12,共3页Chinese Journal of Comparative Medicine

基　　金：南京总医院基金资助;编号:2011001

摘　　要：目的了解先天性白内障大鼠的生物学特性。方法用原种群繁殖扩群,每组选用10对大鼠进行繁殖实验,观察繁殖性能及仔鼠的生长发育。结果白内障大鼠组、小眼白内障组与正常对照组间的产仔数和离乳数差异均无显著性(p>0.05);体重比,在出生后第2周时白内障大鼠比小眼白内障组和正常对照组体重生长速度快(P>0.05);雄性间比较,2周时白内障大鼠组比其它二组生长速度快,4周时更为明显(P>0.01);雄雌间比较,5周时白内障大鼠组和正常对照组雄雌间生长速度出现差异(P<0.01),小眼白内障组在第6周时生长速度才出现差异(P<0.01)。结论白内障疾病基因对大鼠的繁殖率没有影响,而对仔鼠的生长速度有一定的影响。Objective To explore the biological characteristics of rats with congenital cataract. Methods To expand the populations by breeding with the original group, 10 pairs of rats were used in each group. To observe the reproductive performance and growth and development of the offsprings. Results There were no significant differences in both the birth rate and the weaning number between the normal control group and cataract and microphthalmos cataract groups （P 〉 0.05）. Compared with the other two groups, the cataract group had heavier body weight at the second week after birth. In comparison between males of different groups, the growth of cataract group was faster at first two weeks after birth and the difference in body weight was more obvious at fourth week after birth （P 〈 0.01 ）. In comparison between sexes, there was a significant difference in body weight between male and female rats in the cataract group and the control group at the fifth week after birth （P 〈 0. 01 ）, while the microphthalmos cataract group had significant differences at the sixth week （P 〈 0. 01 ）. Conclusion Cataract gene in rats do not affect their reproductive rate, while there is certain effect on the growth of pups.

关 键 词：先天性白内障 大鼠 繁殖 生长发育 

分 类 号：R33[医药卫生—人体生理学]