急性冠脉综合征早期血清缺血修饰性白蛋白、高敏C反应蛋白及CXC趋化因子配体16水平检测的意义  

Changes and clinical significance of ischemia modified albumin, high-sensitivity C-reactive protein and CXC ligand 16 in early acute coronary syndrome patients

作　　者：顾志淼 羊镇宇[2] 

机构地区：[1]无锡市第八人民医院内科,江苏无锡214011 [2]南京医科大学附属无锡第一医院心内科,江苏无锡214023

出　　处：《江苏大学学报（医学版）》2013年第4期317-319,324,共4页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:探讨急性冠脉综合征(acute coronary syndrome,ACS)患者早期缺血修饰性白蛋白(ischemia modifiedalbumin,IMA)、高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)及CXC趋化因子配体16(CXCL16)血清学筛查的意义。方法:选取93例在胸痛3 h内就诊的患者,即时抽血检测IMA、hs-CRP及CXCL16;根据临床诊断标准,其中63例ACS患者入选ACS组,30例排除ACS的胸痛患者入选对照组;比较两组IMA、hs-CRP及CXCL16水平。结果:ACS组患者血清IMA、hs-CRP及CXCL16水平均显著高于对照组(均P<0.01);相关分析显示ACS患者血清IMA水平与hs-CRP及CXCL16之间均呈显著性正相关(r=0.286,P<0.05;r=0.301,P<0.05)。结论:IMA、hs-CRP及CXCL16与ACS的发生关系密切,早期联合检测有助于ACS患者的早期诊断及风险评估。Objective： To explore the values of the serological screening for the ischemia modified albumin（IMA）,high-sensitivity C-reactive protein（hs-CRP） and CXC ligand 16（CXCL16） in early acute coronary syndrome（ACS） patients.Methods： A total of 93 patients who were admitted to hospital in 3 hours after chest pain occurred were recruited and divided into control group（n = 30） and acute coronary syndrome group（ACS n = 63）,IMA,hs-CRP and CXCL16 were detected by intravenous haemospasia and compared between the two groups.Results： The levels of serum IMA,hs-CRP and CXCL16 in ACS group were increased significantly compared with the control group（all P 0.01）.The results of correlation analysis showed that IMA had a positive correlation with hs-CRP and CXCL16（r = 0.286,P 0.05;r = 0.301,P 0.05）.Conclusion： IMA,hs-CRP and CXCL16 were correlated with ACS,and CXCL16 was probably one of the responsible factors of the high serum IMA and hs-CRP levels.They could be the earliest sensitive indicators to the diagnosis and risk estimation of ACS.

关 键 词：急性冠脉综合征 缺血修饰性白蛋白 高敏C反应蛋白 CXC趋化因子配体16 

分 类 号：R541.4[医药卫生—心血管疾病]