排卵障碍患者的临床观察及治疗  

Clinical observation and treatment of ovulation dysfunction

作　　者：颜耀华[1] 李力[1] 郑英如[1] 郭建新[1] 唐宇铃[1] 申启玲[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所妇产科,重庆400042

出　　处：《重庆医学》2013年第36期4387-4389,共3页Chongqing medicine

基　　金：第三军医大学校管课题(2007xg063)

摘　　要：目的通过对排卵障碍患者的观察和治疗资料进行临床分析,探讨排卵障碍性不孕症的临床特点及治疗策略。方法回顾分析2008年4月至2012年4月中630个B超监测自然排卵周期和促排卵周期的临床资料,分析排卵障碍的常见病因、临床表现以及不同促排卵方案的临床结局。结果自然排卵周期中排卵障碍周期约占41.61%,排卵障碍周期中以多囊卵巢综合征(PCOS)患者最为常见。通过促排卵治疗,60.84%的治疗周期有正常排卵,其中克罗米酚50mg方案及克罗米酚50mg联合尿促性素方案治疗周期排卵成功率较高,分别为66.49%、67.57%,与其他方案比较,差异有统计学意义(P<0.05)。排卵障碍以无排卵为主要表现,其次为小卵泡排卵及卵泡黄素化未破裂。结论排卵障碍是不孕症常见病因,明确其病因及临床特点,制订适宜、高效的促排卵治疗方案可提高其正常排卵率,增加受孕机会。Objective Through observing and treating the ovulation dysfunction patients with birth demand ,to study the clinic characteristics and therapy strategy .Methods 630 clinical cases including natural cycles and controlled ovarian stimulated cycles . monitored by transvaginal B-ultrasonography from April 2008 to April 2012 ,The common reasons ,clinical manifestation ,and out-come undergoing different treatment strategies were analyzed .Results In the natural cycles ,41 .61% patients suffered ovulation dysfunction ,PCOS patients occupied the most .Through the therapy of controlled ovarian stimulating on these patients ,60 .84% of ovulation dysfunction patients recovered normal ovulation .The therapeutic regimen of clomiphene citrate （CC） 50 mg and of CC combined with human menopausal gonadotropin（HMG） showed a higher ovulation rate ,66 .49% and 67 .57% respectively（P〈0 .05） .Anovulia was the most commonly type of the ovulation dysfunction ,followed small follicle ovulation and luteinizing unrup-tured follicle .Conclusion Ovulation dysfunction is frequent in infertility patients .Understanding the clinical characteristic and the disease cause ,working out the favourable and effective therapeutic regimen can increase their conception possibility .

关 键 词：无排卵 排卵诱导 多囊卵巢综合征 

分 类 号：R711.75[医药卫生—妇产科学]