联合检测CEA、NSE及CYFRA21-1对胸腔积液性质鉴定的临床价值  

The Clinical Value of Combined Detection of CEA,NSE and CYFRA21-1 in Differential Diagnosis of Benign and Malignant Hydrothorax

作　　者：蒋长斌[1,2] 崔邦平[1,2] 代文莉[2] 刘玉文[2] 杨建华[2] 王朋[2] 

机构地区：[1]三峡大学第一临床医学院,湖北宜昌443003 [2]湖北省宜昌市中心人民医院,湖北宜昌443003

出　　处：《标记免疫分析与临床》2013年第6期401-403,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨胸腔积液及血清肿瘤标志物癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白片段21-1(CYFRA21-1)联合检测在鉴别诊断胸腔积液性质中的意义。方法采用双抗体夹心磁微粒化学发光法分析42例确诊为肺癌患者和65例确诊为肺炎患者胸水和血清中CEA、NSE及CYFRA21-1浓度,对两组进行比较。结果肺癌组胸水及血清肿瘤标志物CEA、NSE及CYFRA21-1测定值均显著高于肺炎组,差异有统计学意义(P<0.01)。灵敏度和准确度高于单项检测的灵敏度和准确度。结论胸水和血清3种肿瘤标志物联合检测胸腔积液性质的诊断效能高于单项检测;胸水检测的灵敏度及准确度高于血清学检测。Objective To explore the value of combined detection of CEA, NSE and CYFRA21-1 in differential diagnosis of hydrothorax with serum and hydrothorax. Methods The hydrothorax and serum CEA, NSE and CYFRA21-1 levels in 42 lung cancer and 65 pneumonia patients were detected by double-antibody sandwich ehemolumineseenee. Results The hydrothorax and serum level of CEA, NSE and CYFRA21-1 in the lung canc- er patients were significantly higher than that of pneumonia group （ P 〈 0.01 ）. The sensitivity and accuracy of combined CEA, NSE and CYFRA21-1 were higher than each sigle test Conclusion The sensitivity and accura- cy of combined detection of CEA, NSE and CYFRA21-1 in serum and hydrothorax are remarkably higher than each single test. The detection of hydrothorax was more valuable than the serum detection.

关 键 词：肺癌 胸腔积液 CEA NSE CYFRA21-1 

分 类 号：R561.3[医药卫生—呼吸系统]