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作 者:崔亚男[1] 管华[1] 刘春华[2] 付英杰[1] 王慧云[1]
机构地区:[1]济宁医学院药学院,山东日照276826 [2]济宁医学院临床学院,山东济宁272067
出 处:《济宁医学院学报》2013年第6期400-401,407,共3页Journal of Jining Medical University
基 金:济宁市卫生局"济宁市中医药科技发展计划项目"(编号:ZY2012004)
摘 要:目的制备白芍提取物肠溶微囊并对其体外释放度进行考察。方法以相凝聚法制备微囊,建立高效液相色谱法测定微囊的载药量与包封率,并考查其体外释放度。结果所得微囊外观圆整,平均粒径为(460±120)μm范围内,载药量为92.3%,包封率为43.04%。所得微囊在模拟胃液中2h内释放量低于10%,在模拟肠液中45min释放量即超过70%。结论白芍提取物所制得的微囊肠溶效果理想。Objective To study on the preparation method and release activity of enteric microcapsules for paeony extraction.Methods Enteric microparticles were prepared by modified coacervation techniques.The HPLC method was found to determine the drug loading,entrapment efficiency and release activity in vitro.Results The microcapsules were regular in shape and the average particle size was(460±120)μm.The drug loading and entrapment efficiency were 92.3%and 43.04%respectively.The releasing experiment in vitro showed that the drug release amount was less than 10%in simulated gastric fluid within2h while the amount was more than70%in simulated intestinal fluid only in 45min.Conclusion The microcapsules show significant enteric release character.
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