宽戟橐吾中苯并呋喃衍生物及其体外细胞毒活性研究(英文)  

Benzofuran Derivatives from Roots of Ligularia Latihastata and in Vitro Cytotoxic Activity

作　　者：王蓓[1] 高玲焕[1] 张继虹[1] 李蓉涛[1] 李海舟[1] 

机构地区：[1]昆明理工大学生命与科学技术学院,昆明650500

出　　处：《昆明理工大学学报（自然科学版）》2013年第6期89-92,共4页Journal of Kunming University of Science and Technology(Natural Science)

基　　金：Supported by the National Natural Science Foundation of China(31060054)

摘　　要：从我国民间药用植物菊科宽戟橐吾(Ligularia latihastata)的根茎中分离得到1个新化合物:2-乙酰基-5-甲氧基-6羟基-苯并呋喃(1)和5个已知的苯并呋喃衍生物,其结构通过1D NMR和2D NMR等光谱分析和化学方法确定.通过生物活性筛选研究发现化合物2-异丙基-5-乙酰基-6-羟基-苯并呋喃(2)对人宫颈癌细胞具有较强的细胞毒活性,其IC50值为36.0μmol/L.A new benzofuran derivative, 2-acetyl-5-methoxy-6-hydroxy - benzofuran （ 1 ）, along with five known analogues are isolated from the roots of Ligularia latihastata （compositae） which is used as a folk medicine in China. Their structures are then elucidated on the basis of extensive spectroscopic data, including 1D and 2D NMR techniques. Biological screening studies indicate that 2 - isopropenyl - 5 - acetyl - 6 - hydroxy - benzofu- ran（2 ） exhibites potent cytotoxic activity against Hela human cervical carcinoma cancer cells with IC50 values of 36.0 μmol/L.

关 键 词：宽戟橐吾 菊科 苯并呋喃 细胞毒活性 

分 类 号：R284.1[医药卫生—中药学]