冠状动脉慢血流患者血清E-选择素与高敏C反应蛋白水平的变化  

Changes of serum levels of E-selectin and high sensitivity C-reactive protein in patients with slow coronary flow

作　　者：贺立群[1] 雷健[1] 王顺[1] 李佐民[1] 昌薇[1] 柯于鹤[1] 邓次妮[1] 张帆[1] 文飞[1] 冷沁[1] 郑蓉[1] 陈海云[1] 欧阳银娥 

机构地区：[1]武汉市第一医院,武汉430022

出　　处：《内科急危重症杂志》2013年第6期348-349,共2页Journal of Critical Care In Internal Medicine

基　　金：武汉市卫生局资助课题(No:2010WX10C05)

摘　　要：目的:了解炎症反应在冠状动脉慢血流(SCF)现象中的作用及临床意义。方法:60例在我院进行冠状动脉造影检查未发现明显冠状动脉狭窄的患者,均采用TIMI血流帧数计数来评价冠状动脉的血流速度,根据造影结果分为SCF组以及冠状动脉正常血流组(NCF组),每组各30例,对2组患者的临床特点、血清可溶性SES、高敏C反应蛋白(hs-CRP)水平进行比较分析。结果:SCF组患者血清SES及hs-CRP水平明显高于NCF组(58.60±3.96 vs 43.83±3.50ng/mL;3.92±0.40 vs 2.58±0.22μg/mL,P<0.01),且hs-CRP水平的高低与平均TIMI血流帧数结果明显正相关(r=0.830,P<0.01)。结论:SCF患者血清SES以及hs-CRP水平的升高,提示炎症反应可能与SCF现象的发生有关。Objective： To detect the role of inflammatory response and its significance in patients with slow coronary flow （SCF） . Methods： A total of 60 patients without obvious coronary stenosis by angiography were divided into SCF group and normal coronary flow （NCF） group （30 cases for each group） . Clinical manifestations, serum levels of soluble E-selectin （SES） and high sensitive C-reactive protein （hs-CRP） were compared and analyzed in two groups. Results ： Serum levels of SES and hs-CRP were significantly higher in SCF group than those in NCF group （ 58.60 ±3.96 vs 43.83 ＋ 3.50ng/mL ; 3.92 ± 0.40 vs 2.58 ±0.22 μg/mL, P 〈 0.01 ）, and serum level of hs-CRP is positively correlated with the average TIMI frame count （r = 0. 830,P 〈 0.01 ）. Conclusion： Increased serum levels of hs-CRP and SES in patients with SCF may be an indicator of inflammatory response and play an important role in the pathogenesis of SCF phenomenon.

关 键 词：冠状动脉慢血流 可溶性E-选择素 高敏C反应蛋白 

分 类 号：R541[医药卫生—心血管疾病]