子痫前期患者血清25-羟维生素D水平检测的临床意义  

Clinical significance of serum 25-hydroxyvitamin D levels in preeclampsia patients

作　　者：罗颖贞 侯延庆[1] 尹昕[1] 

机构地区：[1]广东医学院附属南山医院,广东深圳518052

出　　处：《国际检验医学杂志》2013年第24期3318-3319,共2页International Journal of Laboratory Medicine

基　　金：深圳市南山区卫生科技资助项目(南科研卫2012024)

摘　　要：目的探讨子痫前期患者血清25-羟维生素D[25-(OH)D]水平检测的临床意义。方法采用ELISA法及离子选择电极法测定200例妊娠期高血压疾病(妊娠高血压41例、子痫前期轻度30例、子痫前期重度131例)及300例正常晚期妊娠妇女血清25-(OH)D及钙的水平。结果正常晚期妊娠组血清钙水平(2.46±0.11)mmol/L,25-(OH)D水平(51.37±13.19)nmol/L,均明显高于妊娠期高血压疾病组(P<0.05),妊娠期高血压疾病组血清钙水平(2.16±0.12)mmol/L,25-(OH)D水平(40.46±11.89)nmol/L;轻度子痫前期组血清钙水平(2.12±0.12)mmol/L,25-(OH)D水平(37.92±8.55)nmol/L,均明显高于重度子痫前期组(P<0.05),重度子痫前期组血清钙水平(1.89±0.14)mmol/L,25-(OH)D水平(28.05±10.4)nmol/L;晚发型重度子痫前期血清钙水平(1.86±0.13)mmol/L,25-(OH)D水平(27.12±9.1)nmol/L,均明显高于早发型(P<0.05),早发型血清钙水平(1.65±0.16)mmol/L,25-(OH)D水平(20.36±6.54)nmol/L;妊娠期高血压组与子痫前期轻度组血清钙及25-(OH)D水平差异无统计学意义(P>0.05)。结论低水平血清25-(OH)D可能与子痫前期的发生、发展有关。Objective To study the clinical significance of serum 25-hydroxyvitamin D [25-（OH）D] levels in preeclampsia pait- ents. Methods 200 women with hypertensive disorder complicating pregnancy（HDCP） were enrolled in the study, including 41 women with pregnancy hypertension, 30 women with mild preeclampsia and 131 women with severe preeclampsia. 72 normal late pregnant（NLP）women were involved. The levels of serum calcium were measured by ion selective electrode method, and the levels of serum 25-（OH）D were measured by ELISA. Results The levels of serum calcium and 25-（OH）D were significantly higher in NLP women than in women with HDCP,P〈0.05. The levels of serum calcium and 25-（OH）D were significantly higher in women with mild preeelampsia（mPE） than in women with severe preeclampsia（sPE） ,P〈0.05. The levels of serum calcium and 25-（OH） D were significantly higher in late onset severe preeclampsia（LOSP） than in women with early onset severe preeelampsia（EOSP）, P〈0.05. There was no difference between women with HDCP and women with mPE（P〉0.05）. Conclusion The lower levels of serum vitamin D probably related to the occurrence and development of preeclampsia.

关 键 词：血清钙 25-羟维生素D 子痫前期 

分 类 号：R714.245[医药卫生—妇产科学]