白细胞介素8在冠心病中的研究进展  

The Research Advances of Interleukin-8 in the Coronary Heart Diseases

作　　者：吴彩凤[1] 殷惠军[1] 

机构地区：[1]中国中医科学院西苑医院心血管实验室,北京100091

出　　处：《医学综述》2013年第24期4417-4420,共4页Medical Recapitulate

基　　金：国家自然科学基金(81073086)

摘　　要：典型趋化因子白细胞介素(IL)8在冠状动脉粥样硬化性疾病的发病中具有促进单核细胞和内皮细胞黏附的作用,从而参与冠状动脉粥样硬化疾病的早期病变;而且IL-8不仅促进动脉粥样硬化的炎性反应,还可促进动脉粥样硬化斑块内血管新生,从而导致动脉粥样硬化斑块破裂,触发急性冠状动脉事件的发生。IL-8作为冠状动脉粥样硬化性心脏病的重要危险因素,其血清学水平与急性心肌梗死疾病转归过程中心室纤颤的发生及心功能状态明显相关。Interleukin-8,a typical chemokine,plays a role in the pathological process of coronary heart disease（ CHD）. It promotes the adherence of monocytes to endothelial cells and thus involved in the early lesion of atherogenesis. Interleukin-8 is a potent angiogenic factor,which not only promotes the inflammation in the process of atherosclerosis,but also induces the rupture of atherosclerotic plaque and tigers the acute coronary event. As an important CHD risk factor,serum level of interleukin-8 in AMI is significantly associated with the presence of complications such as ventricular fibrillation and heart function.

关 键 词：白细胞介素8 冠心病 动脉粥样硬化 血管新生 

分 类 号：R543.5[医药卫生—心血管疾病] R34[医药卫生—内科学]