植物来源细菌外排泵抑制剂研究进展  

Progress on Bacterial Efflux Pump Inhibitors of Plant Sources

作　　者：朱晓明[1] 田春莲[1] 张德显[1] 李晶[1] 刘明春[1] 

机构地区：[1]沈阳农业大学畜牧兽医学院,辽宁沈阳110866

出　　处：《动物医学进展》2013年第12期170-173,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31272601)

摘　　要：随着抗菌药物在临床上的广泛使用,细菌的耐药问题日益突出,其中主动外排是导致细菌产生多重耐药的重要原因。逆转细菌耐药已成为当今研究的热点,外排泵抑制剂可以抑制细菌对进入胞体内药物的外排作用,从而提高耐药细菌对药物的敏感性。有研究显示植物提取物具有抑制细菌外排的作用,论文就近年来有关植物来源外排泵抑制剂的研究进展进行了综述。With the widespread use of antibacterial agents in clinic,the problem of bacterial resistance has become increasingly prominent,and active efflux is an important cause of multiple drug-resistant of bacteria.Reverse of bacterial resistance has become hot spots in the study.Efflux pump inhibitors can inhibit bacteria from discharging the drug which has entered its body,thereby enhancing the sensitivity of resistant bacteria to the drug.Studies have shown that plant extracts have the function of inhibiting bacterial efflux.This article reviewed the researches in recent years about the new progress on efflux pump inhibitors from plant.

关 键 词：耐药 外排泵 外排泵抑制剂 植物 细菌 

分 类 号：S859.7[农业科学—临床兽医学]