外源性H_2S对氯胺酮全麻大鼠麻醉时间、麻醉效果的影响  

Effect of exogenous H_2S on anesthesia time and anesthesia effect of ketamine in rat

作　　者：范宏刚[1] 冯国峰[1] 郭蔚[1] 姜胜[1] 刘克祥[1] 邹晶[1] 冀伟[1] 白春杨[1] 

机构地区：[1]东北农业大学动物医学学院,哈尔滨150030

出　　处：《东北农业大学学报》2013年第12期78-83,共6页Journal of Northeast Agricultural University

基　　金：黑龙江省教育厅科学技术研究(面上)项目(12521003)

摘　　要：外源性H2S对中枢神经系统具有一定保护性作用,通过预试验确定NaHS给药时间和剂量,将192只SD大鼠随机均分为4组,分别为对照组(CP组)、低剂量组(LP组,7μmol·kg-1NaHS)、中剂量组(MP组,14μmol·kg-1NaHS)、高剂量组(GP组,28μmol·kg-1NaHS)。在盐酸氯胺酮麻醉前20 min分别给予腹腔注射7、14、28μmol·kg-1NaHS,在麻醉时间、镇痛、镇静、肌松效果等方面观察外源性H2S干预效果。结果表明,外源性H2S呈现剂量依赖性地缩短氯胺酮麻醉的各时期,加强麻醉初期镇痛、肌松效果,可有效提高大鼠氯胺酮麻醉效果。Many studies have shown that the exogenous H2S has a protective effect on the central nervous system, In preliminary experiment, we determined the administration timepoint and dose of NariS. 192 SD rats were randomly divided into 4 groups： control group（CP）, low-dose group （LP, 7 pmol. kg＇NaHS）, medium-dose group （MP, 14 pmol· kg^-1 NariS）, high-dose group （28 μmol·kg^-1 NaHS）. Twenty minutes before ketamine anesthesia, animals in this study were respectively administered 7, 14, 28μmol· kg^-1 NariS by intraperitoneal injection. The interference effect of H2S on anesthesia time, analgesia, sedation, muscle skelaxin were observed. The results shown that the exogenous H2S could shorten the ketamine anesthesia time by dose-dependent, and enhance the effect of ketamine on analgesia and muscle skelaxin.

关 键 词：外源性H2S 氯胺酮 麻醉 

分 类 号：S767.5[农业科学—森林保护学] X172[农业科学—林学]