怀化地区丙肝基因分型分布及临床意义  

The characteristics and clinical significance of HCV genotypes in huaihua area of Hunan province

作　　者：谢知兵[1] 周建亮[1] 李勇忠[1] 邓英[1] 于红英[1] 

机构地区：[1]湖南省怀化市第一人民医院感染科,湖南怀化418000

出　　处：《中国现代医学杂志》2013年第31期43-46,共4页China Journal of Modern Medicine

摘　　要：目的分析怀化地区丙型肝炎病毒基因型分布及其与HCV-RNA载量、肝病程度的相关性。方法对2009年1月~2011年9月200份抗-HCV阳性病人的血清标本进行HCV RNA检测及HCV的基因分型,并分析基因型与HCV RNA含量和肝病程度的相关性。结果基因1b型的HCV RNA载量高于2a型,且差异有显著性。基因1b型的病毒应答率明显低于2a型,且差异具有显著性。HCV感染的不同程度肝病患者的基因型分布差异有显著性,基因1b型比率显著高于其他基因型。结论怀化地区丙型肝炎病毒基因型流行株为2a和1b型,其中以2a为主,HCV基因型与慢性丙型肝炎的严重程度及肝硬化、肝癌的产生有一定的相关性。【Objective】To study the distribution of hepatitis C virus（HCV） genotype in Huaihua region, China and its relationship to HCV RNA content as well as degree of liver disease. 【Methods】The serum specimens from 200 anti-HCV patients from Jan. 2009 to Aug.2010were determined for HCV RNA content and HCV genotype. The relationship of genotype to HCV RNA content and degree of liver disease was analyzed.【Results】The RNA content of HCV of genotype 1b was significantly higher than that of genotype 2a. However, the distribution of genotypes showed significant difference in the patients with liver diseases at various degrees caused by HCV infection.【Conclusion】The epidemic HCV strains in Huaihua region were of genotypes 2a and 1b. HCV genotype showed a certain relationship to the severity of chronic hepatitis C and the onsets of liver cirrhosis and liver cancer.

关 键 词：丙型肝炎病毒 基因分型 

分 类 号：R512.63[医药卫生—内科学]