心痛灵Ⅱ号对结扎冠脉致大鼠心肌缺血的保护作用  

PROTECTIVE EFFECT OF XINTONGLINGⅡ ON RAT'S ACUTE MYOCARDIAL ISCHEMIA CAUSED BY LIGATE CORONARY ATERIES

作　　者：王行宽[1] 肖瑄[2] 

机构地区：[1]湖南中医学院一附院,长沙410007 [2]湖南中医学院,97研究生长沙410007

出　　处：《中国中医药科技》2000年第6期363-364,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：湖南省卫生厅课题

摘　　要：本研究观察了中药复方心痛灵Ⅱ号消化道给药对实验性心肌缺血大鼠心肌梗塞面积以及血清肌酸磷 酸激酶（ＣＫ）、血浆内皮素（ＥＴ）活性的影响。结果显示：心痛灵Ⅱ号可明显缩小心梗面积，抑制ＣＫ的溢出和血 浆ＥＴ的过量释放，与盐水组及其阳性药对照组比较差异显著（Ｐ＜０．０５～０．０１），从而保护心肌免受缺血性损 伤。心痛灵Ⅱ号独具疏肝解郁之功效，说明疏肝解郁法是治疗冠心病心绞痛的重要法则之一。In order to prove the protective effect of Xintongling Ⅱon rat's myocardial lschemia caused by ligate-coronary-ateries, the changes of myocardial infarction areas, serum creatine phosphokinase (CK) and plasma endothelin (ET) in rat with experimental acute myocardial ischemia were observed. The results showed that Xintongling Ⅱcould significantly reduce the myocardial infarction areas, inhibite the overflow of CK and control the over release of ET, there were significant difference between Xintongling Ⅱand the others (P＜0.05-0.01), these indicated that Xintongling Ⅱcould effectively protect myocardial ischemia from damage. Xintongling Ⅱcontained Chinese herbs for dispersing the stagnated liver-energy, there suggest that dispersing the stagnated liver-energy is one of the important rule for the treatment of coronary atherosclerotic heart disease

关 键 词：心肌缺血 中医药疗法 ＠心痛灵Ⅱ号 冠脉结扎 

分 类 号：R285.5[医药卫生—中药学]