Ⅲ型前列腺炎患者前列腺液中性粒细胞弹性蛋白酶、枸橼酸和pH值水平分析  

Measurement of neutrophil elastase, citric acid and pH in prostatic fluid of type Ⅲ prostatitis

作　　者：王宝龙[1] 董治春[1] 杨长海[1] 

机构地区：[1]天津医科大学总医院泌尿外科,300052

出　　处：《中华全科医师杂志》2013年第12期970-973,共4页Chinese Journal of General Practitioners

摘　　要：目的 了解中性粒细胞弹性蛋白酶（NE）、枸橼酸和pH值在Ⅲ型前列腺炎患者前列腺液中的变化.方法 对52例ⅢA型（ⅢA组）与98例ⅢB型（ⅢB组）患者行前列腺按摩液（EPS）常规检查和细菌培养、美国国立卫生研究院（NIH）-前列腺炎症状评分（NIH-CPSI）、NE和枸橼酸浓度、pH值测定.以105例正常者为对照.结果 ESP中WBC计数、NE和枸橼酸浓度、pH值,ⅢA组分别为（17.9±5.4）个/HP、（898±704） μg/L和（14.5±1.7） ng/L、7.60 ±0.43,ⅢB组分别为（3.9±2.2）个/HP、（93±76） μg/L和（21.9±3.8） ng/L、6.71 ±0.25,对照组分别为（3.6±2.2）个/HP、（86±57） μg/L和（22.5±3.9） ng/L、6.48±0.51.ⅢA组和ⅢB组EPS中NE和枸橼酸浓度、pH值比较,差异有统计学意义（t值分别为8.22、16.64和13.88,均P＜0.05）,NIH-CPSI差异无统计学意义（t=1.90,P＞0.05）;ⅢA组和对照组EPS中WBC计数、NE和枸橼酸浓度、pH值、NIH-CPSI比较,差异有统计学意义（t值分别为18.92、8.47、26.53、18.37和32.47,均P＜0.05）;ⅢB组和对照组EPS中WBC计数、NE和枸橼酸浓度、pH值比较,差异无统计学意义（t值分别为1.38、1.55、1.02和1.21,均P＞0.05）,NIH-CPSI差异有统计学意义（t=49.46,P＜0.05）.EPS中,NE浓度与WBC计数、NIH-CPSI呈正相关（r值分别为0.819和0.698,均P＜0.01）,与枸橼酸浓度呈负相关（r=-0.625,P＜0.01）;枸橼酸浓度与WBC计数、NIH-CPSI、pH值呈负相关（r值分别为-0.728、-0.644和-0.817,均P ＜0.01）.结论 不同亚型的Ⅲ型前列腺炎患者EPS中NE和枸橼酸浓度、pH值等存在差异.Objective To measure the levels of neutrophil elastase （NE）,citric acid and pH in prostatic fluid of patients with prostatitis type Ⅲ.Methods Fifty two patients with prostatitis type ⅢA,98 patients with prostatitis type Ⅲ B and 105 health subjects were enrolled in the study.The levels of NE,citric acid and pH in prostatic fluid were measured ; the expressed prostatic secretion （EPS） routine and bacterial culture were examined,and National Institutes of Health （NIH）-chronic prostatitis symptom index （NIH-CPSI） was evaluated.The data were analyzed by independent samples t-test.Results WBC count,NE and citric acid concentrations,pH in ⅢA group were （17.9 ±5.4）/HP,（898 ±704） μg/L and （14.5 ± 1.7） ng/L,7.60 ±0.43,respectively; those in ⅢB group were （3.9 ±2.2）/HP,（93 ±76） μg/L and （21.9 ±3.8） ng/L,6.71 ±0.25,respectively; those in control group were （3.6 ±2.2）/HP,（86 ±57） μg/L and （22.5 ± 3.9）ng/L,6.48 ± 0.51,respectively.There were significant differences in NE and citrate concentrations,pH value in EPS between Ⅲ A and Ⅲ B patients （t =8.22,16.64 and 13.88,all P ＜0.05）,but no difference in NIH-CPSI （t =1.90,P 8 0.05）.There were significant differences in WBC count,NE and citric acid concentrations,pH in EPS,NIH-CPSI score between Ⅲ A and control groups （t =18.92,8.47,26.53,18.37 and 32.47,all P ＜ 0.05）.There were no differences in WBC count,NE and citric acid concentration and pH value in EPS between Ⅲ B group and control group （t =1.38,1.55,1.02 and 1.21,respectively,all P 80.05）,but there was significant difference in NIH-CPSI score between two groups （t =49.46,P ＜ 0.05）.In EPS,NE concentration and WBC count were positively correlated with NIH-CPSI （r =0.819 and 0.698,respectively,all P ＜0.01）,and citric acid was negatively correlated （r =-0.625,P ＜ 0.01） ; citrate was negatively correlated with WBC count,CPSI and pH value （r =-0.728,-0.644 and-0.817,all P ＜ 0.01）.Conclusions The results

关 键 词：前列腺炎 白细胞弹性蛋白酶 枸橼酸 PH值 

分 类 号：R697.3[医药卫生—泌尿科学]