胸腺素α原对老龄鼠血清中甲状腺激素、糖皮质激素及雌二醇水平的影响  

Effect of prothymosin α on the levels of thyroid hormone and GC and E_2 in serum in aged mice

作　　者：郑金来[1] 刘佃辛[1] 李君文[1] 高兰兴[1] 张符光[1] 王新为[1] 宋农[1] 辛忠涛[1] 

机构地区：[1]军事医学科学院卫生学环境医学研究所,天津300050

出　　处：《微生物学免疫学进展》2000年第4期47-49,共3页Progress In Microbiology and Immunology

摘　　要：采用放射免疫分析检测胸腺素α原对老龄鼠甲状腺激素、糖皮质激素和雌二醇血清水平的影响。结果表明 ,与对照组相比 ,胸腺素α原可明显提高老龄鼠T3 、T4 、E2 、ACTH的血清水平 ,降低TSH和GC的水平。总之 ,胸腺素α原可以通过某一未明的机制调节某些激素的血清水平。To detect the effect of prothymosin α on the levels of thyroid hormone、GC and E 2 in serum in aged mice,sixteen 15 month old female mice were divided into two groups at random:one was treated with prothymosin α intraperitoneally;the other with physiological saline.After 21 days,they were all sacrificed and the levels of hormone in serum were determined by radioimmunoassay.Results showed that compared with control group,prothymosin α significantly increased the levels of T 3、T 4、ACTH and E 2 in serum.However,it markedly decreased the levels of TSH and GC in serum.In a word,prothymosin α was involved in the regulation of some species of hormones in serum by an unknown mechanism.

关 键 词：胸腺素Α原 老龄 甲状腺激素 糖皮质激素 雌二醇 

分 类 号：R592.05[医药卫生—老年医学] R977.1[医药卫生—内科学]