蒙药达日布-8丸对高脂血症大鼠调节血脂作用的实验研究  

The experimental study on the effect of Mongolian medicine Daribu-8 pill on regulating blood lipid of hyperlipidemia rats

作　　者：李姹润 孟根杜希[1] 孟根达来[2] 张冲[3] 哈申图雅[1] 松林[1] 

机构地区：[1]内蒙古医科大学蒙医药学院,呼和浩特硕士研究生010110 [2]内蒙古医科大学第一附属医院,呼和浩特010110 [3]内蒙古医科大学基础医学院,呼和浩特010110

出　　处：《环球中医药》2013年第11期819-821,共3页Global Traditional Chinese Medicine

基　　金：内蒙古自治区高等学校科研研究项目(NJ10138)

摘　　要：目的观察蒙药达日布-8丸对高脂血症大鼠血脂的调节作用。方法取50只Wistar大鼠,随机分为5组,每组10只,设立正常对照组、高脂血症模型组、蒙药达日布-8高、低剂量组及血脂康组,基础饲料喂养1周后,每组每天给予相应饲料饲喂及药物灌胃给药,连续12周,末次给药后断头取血,分离血清,送检血脂。结果与正常对照组相比,高脂血症模型组明显升高大鼠血清总胆固醇,同时降低高密度脂蛋白(P<0.01),说明高脂血症模型大鼠制作成功。达日布-8高剂量组及低剂量组均可明显降低血清总胆固醇及甘油三酯,与高脂血症模型组相比有显著性差异(P<0.01)。达日布-8高剂量组与血脂康组相比可以明显降低血清总胆固醇及低密度脂蛋白(P<0.05)。但达日布-8丸高、低剂量组对高密度脂蛋白的影响与高脂血症模型组相比则无显著性差异。结论蒙药达日布-8丸对于高脂血症模型大鼠具有显著的调节血脂作用。Objective To observe the regulating effect of Mongolian medicine Daribu-8 pill on hyperlipidemia rats. Methods Fifty Wistar rats were randomly divided into 5 groups, with 10 rats in each group, involving normal control group, hyperlipidemia model group, Mongolian Daribu-8 high and low dose group and Xuezhikang group. Each group was given the corresponding drug administered orally every day, totally for 12 weeks. When the last administration was finished, rats blood was decapitated for the blood, and the serum was separated for blood lipid test. Results Compared with the normal control group, hyper- lipidemia model group was significantly increased in rats and reduce serum total cholesterol, high density lipoproteiu （P 〈 0. 01 ） , the model of hyperlipidemia rats success. Daribu-8 high dose group and low dose group can significantly reduce the serum total cholesterol and triglyceride, there was significant difference compared with the hyperlipidemia model group （P 〈 0. 01 ）. Compared Daribu-8 high dose group and Xu- ezhikang group can obviously reduce the serum total cholesterol and low density lipoprotein （ P 〈 0. 05 ）. But Daribu - 8 pill high and low dose group of high density lipoprotein compared with the hyperlipidemia model group showed no significant difference. Conclusion Mongolian medicine Daribu-8 pill has signifi- cant moderation effect for hyperlipidemia model rats.

关 键 词：高脂血症 达日布-8丸 沙棘 蒙药 

分 类 号：R29[医药卫生—民族医学]