北京市某社区汉族男性维生素D营养状态及与骨转换指标的关系  

Effect of vitamin D status on bone turnover markers among Han-Chinese men in a Beijing Community

作　　者：裴育[1] 刘敏燕[1] 卢艳慧[1] 成晓玲[1] 方福生[1] 马丽超[1] 金萌萌[1] 李楠[1] 钟文雯[1] 李剑[1] 李春霖[1] 

机构地区：[1]解放军总医院老年内分泌科,北京100853

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2013年第4期308-313,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：目的 探讨北京市某社区汉族男性钙调激素及骨转换指标的变化特征.方法 回顾性分析2012年北京市某社区2 792名汉族男性查体者的一般资料、钙调激素25羟维生素D（25OHD）、甲状旁腺素（PTH）及骨转换指标I型原胶原氨基末端肽（PINP）、骨钙素（OC）、胶原C端交联物（CTX）的测定结果,探讨维生素D营养状态对上述骨转换指标的影响.结果受试者年龄24～97岁,平均（62.79±19.01）岁,血清25OHD水平平均为（19.84±8.65）ng/mL,维生素D充足者占11.96 %,不足者占29.30 %,缺乏者占58.74 %.PTH随年龄增长呈升高趋势（P＜0.001）,与血钙呈负相关（r=-0.3192,P＜0.0001）.OC、PINP及CTX与25OHD负相关（分别r=-0.1690,P＜0.0001;r=-0.1799,P＜0.0001;r=-0.1822,P＜0.0001）.结论北京市某社区汉族男性25OHD水平普遍偏低,与骨转换指标呈负相关.Objective To investigate the changing characteristics of calcium-regulating hormones and bone turn- over markers among Han-Chinese men in a Beijing community. Methods A retrospective analysis was carried out by studying the general infornmtion and the data of ealcium-regulating hormones （25-hydroxyvitamin D [25OHD], parathy- roid hormone [ PTH] ） and bone turnover markers （procollagen type 1 amino-terminal propeptide [ PINP], osteocalcin （OC） , C-terminal cross-linking telopeptide （CTX） from 2 792 Han-Chinese men, who were selected from those atten- ding routine physical examinations in a Beijing community. The effect of vitamin D status on the bone turnover markers was investigated. Results The sample population （ aged 24 to 97 years） , serum concentrations of 25OHD were found to be in the range of 19.84 ＋8.65 ng/mL. Among them, 11.96 % of patients were sufficient, 29.30 % were insufficient and 58.74 % were deficient. The serum PTH concentrations showed a tendency to increase with age （P 〈 0. 001 ） and were negatively associated with serum calcium concentrations （r = -0. 3195, P 〈 0. 0001 ）. The bone turnover markers were negatively associated with 25OHD, OC （r = - 0. 1690, P 〈 0. 0001 ）, P1NP （ r = - 0. 1799, P 〈 0.0001 ） and CTX （ r = - 0. 1822, P 〈 0. 0001 ）. Conclusion Vitamin D insufficiency is highly prevalent among the Han-Chinese men in a Beijing community and the 25OHD were negatively associated with bone turnover markers.

关 键 词：男性 25羟维生素D 骨转换指标 

分 类 号：R681[医药卫生—骨科学]