加兰他敏治疗阿尔茨海默病疗效的meta分析  

Meta analysis on the effect of galantamine in the treatment of Alzheimer's disease

作　　者：任思思[1] 董燕[1] 钟朝晖[1] 

机构地区：[1]重庆医科大学公共卫生与管理学院流行病与卫生统计,重庆400016

出　　处：《激光杂志》2014年第1期66-68,共3页Laser Journal

基　　金：重庆市科技计划项目(编号cstc2011jjA10021)

摘　　要：目的:采用循证医学的方法评价加兰他敏治疗阿尔茨海默病(Alzheimer’s disease,AD)效果。方法:检索国内外发表的有关加兰他敏治疗阿尔茨海默病的随机对照试验(RCTs)文献,采用Meta分析方法,利用RevMan5.0软件评价加兰他敏的疗效。计算合并均数差(MD)和相对危险度(RR)值,95%置信区间(CI),及不良反应发生率。结果:最终纳入11篇RCTs。分析结果显示:在认知能力方面,加兰他敏对AD的MMSE量表评分在治疗后提高(MD=2.04,95%CI:0.77,3.31),在基线分数基础上,ADAS-Cog积分评分下降,有积极作用(MD=-3.20,95%CI:-3.60,-2.80);在生活能力上,加兰他敏对AD的ADL量表评分无明显影响(MD=0.25,95%CI:-1.10,1.60),在DAD量表评分上经加兰他敏治疗后有所提高(MD=4.06,95%CI:3.83,4.28);在行为能力上,加兰他敏对AD的NPI量表评分下降(MD=-1.36,95%CI:-2.21,-0.52);AD患者经加兰他敏治疗对CIBIC-plus分数改变有着积极的作用。不良反应呕吐发生率最高,但对腹泻无明显影响作用。结论:加兰他敏对AD患者在认知、生活能力、行为能力和CIBIC-plus分数改变有一定治疗效果,但仍需更充分的证据。Objective To evaluate the efficacy of galantamine in the treatment of Alzheimer＇s disease. Methods Randomized controlled trials （RCTs） oft galantamine treatment of Alzheimer＇s disease were re- trieved by searching international and national databases. The pooled mean difference and relative risk and 95% CI were assessed by Meta analysis with RevMan 5.0 software. Results 11 RCTs were included. Cognition： the results of meta-analysis showed that the value of MMSE was significantly higher in AD group （MD=2.04,95%Ci：0.77,3.31）, ADAS-Cog change from baseline to endpoint was lower （MD=-3.20,95% CI：-3.60,-2.80） for galantamine in AD group. Function： the pooled mean difference was of ADL （MD=0.25, 95%CI：-1.10,1.60） for galantamine in AD, the pooled mean difference of DAD was （MD=4.06,95%CI： 3.83, 4.28） . Behavior： The value of NPI was significantly lower for galantamine in AD （MD=-1.36,95% CI：-2.21-0.52） .CIBIC-Plus score： positive change after galantamine treatment in AD group. Conclusion Slightly more efficacious changes are in the cognitive, function, behavioral and CIBIC-plus scores for Galantamine in AD. More eligibility trials are needed for providing more evidences.

关 键 词：加兰他敏 阿尔兹海默病 

分 类 号：TN244.1[电子电信—物理电子学]