短指软珊瑚属次级代谢产物化学成分及其生物活性研究进展  

Chemistry and bioactivity of secondary metabolites from the soft corals of the genus Sinularia:research advances

作　　者：梁林富[1,2] 李玉芬[1] 刘海利[1] 郭跃伟[1] 

机构地区：[1]中国科学院上海药物研究所新药研究国家重点实验室,上海201203 [2]中南林业科技大学材料科学与工程学院,长沙410004

出　　处：《国际药学研究杂志》2013年第6期643-669,共27页Journal of International Pharmaceutical Research

基　　金：国家海洋高技术研究发展计划(863计划)资助项目(2011AA09070102;2013AA092902);国家自然科学基金资助项目(81273430;21072204;21021063);中国科学院国家新药研究重点实验室项目(SIMM1203ZZ-03;SIMM1105KF-04);欧盟第七框架IRSES(2010~2014)资助项目

摘　　要：短指软珊瑚属(Sinularia)分布十分广泛,富含结构新颖、生物活性显著的次级代谢产物,已成为国际上海洋天然产物的研究热点之一。该属软珊瑚中的次级代谢产物主要涉及倍半萜、二萜、倍半萜-二萜二聚体、二萜二聚体、降倍半萜、降二萜、降二萜二聚体、杂萜、甾体及其糖苷、神经酰胺、长链烷基糖苷、亚精胺等结构类型,其中很多化合物具有抗肿瘤、抗菌、抗病毒和抗炎等生物活性。本文综述了1975年至2013年4月间报道的短指软珊瑚中的次级代谢产物及其生物活性的研究进展,以期为该领域海洋天然产物的后续研究与开发提供参考。Soft corals belong to the genus Sinularia, an important group of marine invertebrates widely distributed in the coral reefs of the world ocean, and offer an enormous source of novel and biologically active compounds. More and more scientists choose them for the research program of marine natural products. As reported, Sinularia furnish a wealth of secondary metabolites, like ses- quiterpenes, diterpenes, sesquiterpene-diterpene dimers, diterpene dimers, norsesquiterpenes, norditerpenes, norditerpene dimers, meroterpenes, steroids/steroidal glycosides, ceramides, spermidines, and glycolipids, etc. Particularly interesting, these metabolites found from the title genus animals exhibited a wide range of biological activities ranging from antitumor, antifugal, antiviral to anti-in- flammatory activities. This paper reviews the progress in the chemistry and pharmacological activities of the second metabolities from Sinularia during the period from 1975 to April 2013, the aim of which is to provide references for further reaserch on the title genus.

关 键 词：短指软珊瑚属 次级代谢产物 化学成分 生物活性 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]