磺胺嘧啶铈乳膏经大鼠阴道和皮肤给药后体内铈离子分布研究  

Distribution of Cerium Ion in Rats after Vaginal and Dermal Delivery of Sulfadizine Cerium Cream

作　　者：张令春[1,2,3] 李晓天[3] 曹凤秋[1,2] 

机构地区：[1]河南省人民医院 [2]郑州大学附属省人民医院,郑州450003 [3]郑州大学药学院,郑州450001

出　　处：《中国药房》2014年第1期16-18,共3页China Pharmacy

摘　　要：目的:研究磺胺嘧啶铈乳膏经大鼠阴道和皮肤给药后器官组织中铈离子的分布情况。方法:取大鼠随机分为实验组及正常对照组,每组9只,实验组经大鼠阴道给予磺胺嘧啶铈乳膏0.036 g/kg,连续给药6 d;另取大鼠随机分为实验组及正常对照组,每组9只,实验组大鼠皮肤烫伤创面涂抹磺胺嘧啶铈乳膏0.036 g/kg,连续给药6 d。采用火焰原子吸收法测定各组大鼠末次给药后8、24、72 h时心、肝、脾、肺、肾、子宫、阴道黏膜/皮肤中的铈含量。结果:与正常对照组比较,实验组大鼠给药8 h时各器官组织均检出铈,分别为(0.013±0.006)^(0.137±0.039)μg/g,24 h时仅肾、脾、子宫、阴道黏膜/皮肤中检出铈,分别为(0.012±0.011)^(0.085±0.037)μg/g,72 h时各组织器官均未检出铈。结论:磺胺嘧啶铈乳膏经阴道和皮肤给药后均能进入血液循环,主要分布于阴道/皮肤、脾、肾、子宫中,但很快被代谢,不会长期蓄积。OBJECTIVE： To study the distribution of cerium ion in rat＇s tissues and organs after vaginal and dermal delivery of Sulfadizine cerium cream. METHODS： Rats were randomly divided into trial group and normal control group with 9 rats in each group; trial group was given Sulfadizine cerium cream 0.036 g/kg via vagina for consecutive 6 days. Other rats were randomly di- vided into trial group and normal control group with 9 rats in each group; trial group was given Sulfadizine cerium cream 0.036 g/kg on skin wound for consecutive 6 days. The contents of cerium ion were measured 8, 24, 72 h after vaginal by FAAS, includ- ing heart, liver, spleen, lungs, renal, uterus, vaginal mucosa and skin. RESULTS： Compared with normal control group, cerium found in various organs 8 h after administration were （0.013 ±0.006）-（0.137 ±0.039） μg/g 8 h after vaginal and dermal delivery; the contents of cerium in renal, spleen, uterus and vaginal mucosa/skin were （0.012 ±0.011）-（0.085 ±0.037） μg/g 24 h after ad- ministration. After 72 h, no cerium could be detected. CONCLUSIONS： After vaginal and dermal delivery, Sulfadiazine cerium cream could be absorbed to blood circulation system and mainly distributed in vaginal mucosa, spleen, lung and uterus. As time go- ing on, cerium could soon be metabolized basically, and would not accumulate in the body in long term.

关 键 词：磺胺嘧啶铈乳膏 大鼠 阴道给药 皮肤给药 组织分布 

分 类 号：R722.142[医药卫生—儿科] R944.2[医药卫生—临床医学]