仔猪痢清口服液对小鼠的亚慢性毒性试验  

Subchronic Toxicity Test of Zizhuliqing Oral Liquid on Mouse

作　　者：洪伟鸣[1] 左伟勇[1] 宋亮[1] 崔潇婷[1] 郁杰[1] 

机构地区：[1]江苏畜牧兽医职业技术学院,江苏省动物药品工程技术研究开发中心,泰州225300

出　　处：《基因组学与应用生物学》2013年第6期725-728,共4页Genomics and Applied Biology

基　　金：江苏省泰州市科技发展计划项目(2013);江苏牧院2012年院级课题(QN1204)共同资助

摘　　要：根据农业部《兽药试验技术规范汇编》观察了仔猪痢清口服液对小白鼠的亚慢性毒性,试验组分设高、中、低3个剂量组,另设空白对照组,连续给药28 d后剖杀各组小鼠。统计学分析结果表明,各组间的体重变化和脏器系数比较无显著差异;各试验组的血常规检测指标、血液生化学检测指标的测定结果与空白对照组测定结果相比差异均不显著;组织病理学检查显示小鼠的主要内脏器官未见明显异常变化。试验结果表明仔猪痢清口服液按临床剂量使用无毒性反应,应用安全可靠。To study the subchronic toxicity of the Zizhuliqing oral liquid, the test was conducted in accordance with the animal drug technological specification compile of Ministry of Agriculture. Experiment mouse were divide into 4 groups, the 3 experiment groups were given Zizhuliqing oral liquid by oral gavage for 28 days at dose levels of 0.01 mL/g.body, 0.02 mL/g.body, 0.04 mUg.body weight per day. The control group was given saline. Results showed that the body weight, organ coefficient, the index of hematology and blood biochemistry were not signifi- cantly different from that in the control group （p 〉0.05）. In addition, results of histopathology examination showed that no obvious abnormalities in the major organ of mice were found among experimental groups after administra- tion of the Zizhuliqing oral liquid. Therefore, our study suggested that the Zizhuliqing oral liquid had no subchronic toxicity and could be safely used for experimental animals.

关 键 词：仔猪痢清口服液 小鼠 亚慢性毒性试验 

分 类 号：S858.28[农业科学—临床兽医学]