Thyroid Examination in Low-Radiation Exposed Iraqi Clean-up Workersmlmmunogenetic Study  

作　　者：Mithal Abdulkareem Abd Oun Amina Naama AL-Thwani Saad Hussein Khudaier Laith Abd al-elahKamel 

机构地区：[1]Department of Bio detection, Directorate of environment and water, Ministry of Science and Technology (MOST), Baghdad 10001,Iraq [2]Department of Immunogenetic, Genetic Engineering and Biotechnology Institute for Post Graduate Studies, University ofBaghdad, Baghdad 10001, lraq [3]Histocompatibility Laboratory, AI-Karama Hospital, Baghdad 10001, Iraq

出　　处：《Journal of US-China Medical Science》2013年第3期85-92,共8页美中医学（英文版）

摘　　要：Aim： Twenty nine Iraqi cleanup workers at A1-Tuwaitha Research site were examined for the prevalence of thyroid disorders. Materials and Methods： Serological evidence were carried out by measuring the levels of triiodothyronine （T3）, thyroxin （T4）, thyroid stimulating hormone （TSH） and anti-thyroglobulin （anti-Tg）, anti-thyroperoxidase （anti-TPO） auto antibodies. Genotyping for HLA-DRB1 and HLA-DQB1 alleles was done by using the molecular biological technique of polymerase chain reaction-sequence specific oligonucleotide （PCR-SSO）. Results： The hormonal study revealed that T4 and T3 levels were below the normal range in five and four workers respectively, TSH was below the normal range in two （7%） workers and elevated in the other three workers （10%）. Anti-TPO and anti-Tg antibodies were also determined. The results were positive in 24% and 17% of cleanup workers respectively. Comparison between 16 cleanup workers group A （risk-group）, 13 group B （exposed） and 30 （non exposed） control showed that HLA-DQBI＊06 allele was significantly P = radiation was most prominent in HLA-DQB 1＊03, P = 0.4 when age-dependent heterogeneity in response to low doses of radiation be involved in decreased thyroid disorder risk. 0.01 lower among group A than controls group. Risk elevation by compared with exposed control. Conclusion： Our data suggest an and the immunogenetic marker such as HLA- DQB 1＊06 allele may

关 键 词：Thyroid disorders HLA-DQB 1 HLA-DRB I 

分 类 号：Q591.5[生物学—生物化学] TQ171.724[化学工程—玻璃工业]