婴幼儿女童乳房早发育与内分泌干扰物相关性分析  

Correlation analysis of premature thelarche and endocrine disruptors in infant girls

作　　者：杨玉[1] 王荻兰 卢庆红[1] 杨利[1] 谢理玲[1] 涂琼[1] 

机构地区：[1]江西省儿童医院内分泌遗传代谢科,南昌330006

出　　处：《国际内分泌代谢杂志》2014年第1期1-4,9,共5页International Journal of Endocrinology and Metabolism

基　　金：江西省科技厅立项课题资助项目（20121BBG0043）

摘　　要：目的探讨0—2岁女童乳房早发育与内分泌干扰物双酚A、邻苯二甲酸二乙酯的相关性。方法采用“病例-对照研究”，收集2012年4—8月在江西省儿童医院诊断为乳房早发育的女童（PT组）50例、健康女童50例（对照组），年龄3个月～2岁，填写调查问卷表；对两组进行子宫、乳房的彩色B超检查；应用化学发光免疫分析仪检测两组血清雌二醇、卵泡刺激素、黄体生成素含量；应用高效液相色谱法测定其血清双酚A、邻苯二甲酸二乙酯含量。结果胛组和对照组均有部分女童检测出双酚A，检出人数分别为48例和9名；部分胛组女童（24例）检测出邻苯二甲酸二乙酯，对照组均未检测出邻苯二甲酸二乙酯。两组血清双酚A、邻苯二甲酸二乙酯含量有差异（Z=-8．018，P〈0．01；Z=-5．522，P〈0．01），且门组均高于对照组。PT组子宫体积与双酚A含量呈正相关（r=0．355，P〈0．05）。PT组血清双酚A、邻苯二甲酸二乙酯含量与血清雌二醇、卵泡刺激素、黄体生成素含量无明显相关性（χ2=6．08，P〉0．05）。患儿血清邻苯二甲酸二乙酯含量有地域差异，城市患儿高于农村患儿（P〈0．05）。结论内分泌干扰物双酚A和邻苯二甲酸二乙酯与婴幼儿女童乳房早发育有关。Objective To investigate the association between premature thelarche and endocrine disrupting compounds bisphenol A, diethyl phthalate in 0-2 years old girls. Methods Using case-control study method ,50 girls with premature thelarehe diagnosed in Jiangxi Provincial Children＇s Hospital,from April to August 2012,were assigned in PT group and 50 healthy girls were assigned in control group.Their age was from 3 months to 2 years old.All should fill out the survey questionnaire.Uterus and breast were measured by Color B-mode ultrasound.Serum estradiol,follicle-stimulating hormone,luteinizing hormone levels were detected by chemiluminescence immunoassay analyzer.Serum bisphenol A, diethyl phthalate were determined by high performance liquid chromatographic method. Results 48 of PT group and 9 of control group were detected bisphenol A,24 of PT group and none in control group were detected diethyl phthalate.The serum levels of bisphenol A, diethyl phthalate in both group were statistiealy different （Z =-8.018, P〈 0.01 ; Z =-5.522, P〈 0.01 ）, and higher in PT group than those in control group.There was a positive correlation between uterine volume and bisphenol A in PT group （r =0.355, P〈 0.05 ）.There was not significant correlation between serum bisphenol A ,diethyl phthalate and serum estradiol,follicle-stimulating hormone, luteinizing hormone in PT group （P 〉0.05 ）.There existed geographical difference in serum diethyl phthalate, and serum diethyl phthalate in urban children was higher than that in rural children （χ2 =6.08, P〈 0.05）. Conclusion Endocrine disrupting compounds bisphenol A and diethyl phthalate are related to premature thelarche in infant girls.

关 键 词：双酚A 邻苯二甲酸二乙酯 婴幼儿 乳房早发育 内分泌干扰物 

分 类 号：R725.8[医药卫生—儿科]