广西城市社区居民高尿酸血症流行病学调查  

Epidemiological survey of hyperuricemia in the Guangxi urban community residents

作　　者：黄江燕[1] 董力[1] 邹贵勉[1] 车文体[1] 眭维国[1] 陈洁晶[1] 邹和群[2] 向月应[1] 

机构地区：[1]解放军第181医院全军器官移植与透析治疗中心,广西代谢性疾病研究重点实验室,桂林541002 [2]南方医科大学第三附属医院肾内科,广州510630

出　　处：《国际内分泌代谢杂志》2014年第1期5-9,共5页International Journal of Endocrinology and Metabolism

基　　金：广西科学研究与技术开发计划资助项目（桂科攻0719-006-2-29）;国际肾脏病学会一全球肾脏病发展委员会资助项目（ISNCOMGAN）

摘　　要：目的研究城市社区居民高尿酸血症（HUA）的患病率及相关危险因素，提出有效防治措施。方法对6273名18～75岁的桂林市象山区城市社区居民进行横断面调查，收集空腹静脉血样本及尿液检测血糖、肾功能、尿常规及尿微量白蛋白等，同时进行问卷调查和体格检查。结果在城市社区居民中HUA的总患病率为23．5％，男性为28．4％，显著高于女性的19．7％（χ2=1332．576，P〈0．01）。校正血肌酐后，血尿酸水平与体重（或体重指数）、腰围、女性年龄等因素有关（r=0．150—0．269，P均〈0.01）。男性受教育程度1～5年组及女性未受教育组血尿酸水平最高，分别为（411．4±91．2）μmol／L和（330．8±78．6）μmol／L。未受教育组HUA的患病率最高（33．6％），受教育程度6～10年组最低（22．4％，P〈0．01）。在男性以无工作组血尿酸水平最高，在女性以家务工作组血尿酸水平最高，分别为（418．9±107．6）μmol／L和（317．2±76．2）μmol／L。无工作组HUA患病率最高（41．0％），体力工作组最低（17．8％，P〈0．01）。饮酒和吸烟对尿酸水平也有显著影响，每天饮酒者和既往吸烟者尿酸水平最高，分别为（399．0±97．9）μmol／L和（408-3±94．6）μmol／L。慢性肾脏疾病（CKD）和高血压患者HUA患病率较高，分别为29．0％和32．0％，平均尿酸水平分别为（354．7±103．6）μmol／L和（356．1±93．9）μmol／L；而糖尿病患者与非糖尿病者HUA患病率无显著差异（χ2=0．957，P〉0．05）。结论广西城市社区居民HUA患病率较高，减轻体重、控制肥胖、避免吸烟、限制饮酒等生活方式的改变可能是有效的防治措施。Objective To explore the incidence of hyperuricemia （HUA） in the urban community residents and the related risk factors, and to propose some effective prevention measures. Methods Totally 6 273 urban residents, aged 18-75 years, were screened with cross-sectional analysis in Xiangshan district of community Guilin.Fasting venous blood samples and urine were collected to evaluate blood glucose,renal function, urine routine, urinary albumin, ete.And questionnaire and physical examination were performed at the same time. Results The total incidence of HUA was 23.5% in the urban community residents,and was 28.4% in males,which was significantly higher than 19.7% in females（ χ2=1 332.576,P〈 0.01 ）.The serum uric acid levels were positive related to weight （or body mass index）, waist circumference and female age when adjusting serum creatinine （r =0.150-0269, all P〈 0.01）. The serum uric acid levels in males received 1 to 5 years education and uneducated females were highest,which were （411.4 ± 91.2）/xmol/Land （330.8 ± 78.6） μmol/L, respectively.The incidence of HUA in uneducated group was highest （33.6%） ,while lowest in 6 to 10 years education group （22.4%, P〈0.01 ）. The serum uric acid levels in males without work and in females engaged in housework were highest,which were （418.9 ± 107.6） Ixmol/L and（317.2 ± 76.2） Ixmol/L, respectively.The incidence of HUA in residents without work was highest （41.0% ）, while lowest in residents engaged in physical work（17.8%, P〈0.01）.Alcohol consumption and smoke influenced significantly on uric acid level, and highest uric acid levels were in the residents frequently drunk [（399.0 ± 97.9） μmol/L] and smoked in the past [（408.3±94.6）μmol/L]. Patients with chronic kidney disease and hypertension had high incidences ofHUA , which were 29.0% and 32.0%, respectively. The mean serum uric acid levels were （354.7 ±103.6）μmol/L and （356.1 ± 93.9）μmol/L in these patients.There was no significant difference

关 键 词：高尿酸血症 社区筛查 患病率 危险因素 

分 类 号：R589.7[医药卫生—内分泌] R181.3[医药卫生—内科学]