蛇毒溶栓酶治疗慢阻肺肺动脉高压的临床研究  

Clinic study of snake venom in treatimg chronic pulmonary arterial hypertension

作　　者：龙学明[1] 李超乾[2] 梁国容[2] 邓家珍[2] 

机构地区：[1]广西中医学院二附院,530011 [2]广西医科大学一附院,530021

出　　处：《广西医学》2000年第6期1182-1184,共3页Guangxi Medical Journal

摘　　要：目的 :观察蛇毒溶栓酶治疗慢阻肺 (COPD)肺动脉高压 (PAH)的临床疗效 ;方法 :通过进行右心导管测定肺动脉平均压 (PAMP)作为主要对照指标 ,对 11例 COPD并 PAH患者 ,进行蛇毒制品 (精制溶栓酶 )的急性药物试验和近期药物试验。结果 :第一次用药后 PAMP平均下降 0 .8m m Hgg (P >0 .0 5 ) ,14天后 PAMP平均下降 8.0 mm Hg (P <0 .0 5) ,PAMP小于 30 m m Hg者 PAH一般能降到正常 ;而 PAMP超过 30 m m Hg者也获得明显下降 ,且 Pa O2 、 Pa CO2 及体循环血压均不受影响。结论 :该药物在近期有理想的降低缺氧性 PAH作用 ,提示其可能为治疗缺氧性 PAH的理想药物 ;有利于肺心病防治。In this study, 11 patients of COPD with pulmonary arterial hypertension(PAH) were treated with snake venom, and right cardiac catheterization was applied to evaluate the acutte effects of venom on changes of pulmonary arterial pressure(PAP). Results: The pulmonary artery mean pressuere(PAMP) of patients was reduced 0.8 mmHg(P>0.05)immediately after injection and 8.0 mmHg(P<0.05)after 14 days. PAH in patients with PAMP<30 mmHg were retured to normal, and those with PAMP>30 mmHg were also desreased significantly while their PaO\-2, PaCO\-2 and system circulation pressure did not changes. This suggested that snake venom is of value in treating hypoxia-induced PAH.

关 键 词：慢性阻塞性肺疾病 肺动脉高压 蛇毒溶栓酶 治疗 

分 类 号：R563.905[医药卫生—呼吸系统] R543.205[医药卫生—内科学]