磁性铁氧化物纳米粒子在药剂学上的应用  

Pharmaceutical Application of Magnetic Iron Oxide Nanoparticles

作　　者：刘军[1] 黄春艳[1] 贺全国[1] 

机构地区：[1]湖南工业大学绿色包装与生物纳米技术应用湖南省重点实验室,株洲412007

出　　处：《化学通报》2014年第1期19-29,共11页Chemistry

基　　金：国家自然科学基金项目(61102031;61001053);湖南省自然科学基金项目(11JJ6038;11JJ5042)资助

摘　　要：磁性铁氧化物纳米粒子(MIONPs)是近几十年发展起来的一种具有磁靶向性的纳米材料,其以良好的磁靶向性、小尺寸效应、生物相容性等特点在生物医学领域具有很好的应用前景,尤其在药剂学领域的应用已经成为一个重要的研究方向。本文在总结近年来国内外有关多功能MIONPs研究成果的基础上,阐述了各种铁氧化物纳米粒子在药剂学领域的应用,主要包括MIONPs的智能载药靶向控释、对特殊药物的靶向负载、降低身体的多药耐药性(MDR)、加强药物治疗效果、载药穿透血脑屏障(BBB)等;并讨论了当前应用中的优点和不足。最后,展望了其在药物、药剂学领域的应用前景并指出了一些亟待解决的问题。Magnetic iron oxide nanoparticles （MIONPs） are excellent magnetic-targeting nanomaterial, which have been greatly developed in recent decades. They have been used in the biomedical field due to their properties of magnetic targeting, small-size effect and biocompatibility. Particularly in pharmaceutics, their applications have become research hotspot. In this paper, the progresses of MIONPs＇ applications in pharmaceutics including intelligent targeting drug controlled release systems, special drugs carriers, modulators for lowering multidrug resistance of body and enhancing pharmaceutical synergistic effect, and that for penetrating into Blood Brain Barrier （BBB） base on domestic and abroad are summarized, and corresponding advantages and disadvantages of these applications have also been discussed. Finally, the main problems and the future development tendency in this field are prospected.

关 键 词：磁性铁氧化物纳米粒子(MIONPs) 智能控释 多肽 基因药物 血脑屏障(BBB) 多药耐药(MDR) 

分 类 号：O614.811[理学—无机化学] R94[理学—化学]