PAI-1对子宫内膜异位症发生发展及临床分期的作用研究  

Effect of PAI-1 on development and clinical stages of endometriosis

作　　者：陈露[1] 有风芝[1] 孙利环[1] 胡孟彩[1] 

机构地区：[1]郑州大学第三附属医院保健部,450052

出　　处：《中国实用医刊》2014年第2期12-14,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨纤溶酶原激活物抑制剂-1（PAI-1）对子宫内膜异位症发生发展的作用。方法应用免疫组化方法检测PAI-1蛋白在40例子宫内膜异位症组异位内膜及在位内膜、30例对照组子宫内膜的表达。结果①PAI-1蛋白主要定位于细胞浆，在异位内膜、在位内膜、对照组内膜的腺上皮细胞及间质细胞均表达；②PAI-1蛋白在异位内膜间质细胞表达高于腺上皮细胞（P〈0．05）；③PAI-1蛋白在间质细胞表达异位内膜高于在位内膜及对照组内膜（P〈0．05）；④PAI-1蛋白在血管内皮细胞呈阳性表达；⑤PAI—1蛋白在异位内膜Ⅲ-Ⅳ期的表达高于I～Ⅱ期及对照组内膜（P〈0．05）。结论PAI-1在异位内膜间质细胞高表达促使其转移、黏附、侵袭、生长，导致子宫内膜异位症的发生发展；PAI-1的作用研究对子宫内膜异位症的临床治疗有一定的指导意义。Objective To investigate the effect of plasminogen activator inhibitor-1 （ PAI-1 ） on genesis and development of endometriosis. Methods Immunohistochemistry method was used to detect the expression of PAI-1 protein in 40 cases of ectopic endometrium, 40 cases of eutopic endometrium and 30 cases of endometrium without endometriosis. Results PAI-1 protein maily localized in cytoplasm, and was expressed in stromal and epithelial cells of ecpotic, eutopic and normal endometrium. The level of PAI-1 protein was significantly higher in stromal ceils than that in epithelial cells of ectopic endometrium（ P 〈 0.05 ）. Endometriotic stromal cells showed significant increasing level of PAI-1 protein, compared with stromal cells of eutopic and normal endometrium （ P 〈 0.05 ）. The level of PAI-1 protein in stage III-IV was significantly higher than that in stage I- II and normal endometrium （P 〈 0.05 ）. Conclusions The overexpression of PAI-! protein in endometriotic stromal cells might be of importance for the migratory, adherance, invasion and growth, which maybe result in endomrtriosis in the end. Studying on the effect of PAI-1 has a certain guiding significance for clinical treatment of endometriosis.

关 键 词：纤溶酶原激活物抑制剂-1 子宫内膜异位症 

分 类 号：R711.71[医药卫生—妇产科学]